FN3K Antibody

1. In a multiple regression analysis, FN3K rs1056534, TF polymorphism and presence of diabetes mellitus were predictors for HHV-8 infection. PMID: 27461879
2. FN3K could act in concert with other molecular mechanisms and may impact on gene expression and activity of other enzymes involved in deglycation process PMID: 26352355
3. Report association of rs1056534 and rs3848403 of fructosamine 3-kinase gene with sRAGE in patients with diabetes. PMID: 24908234
4. The marginal association of rs1056534 of FN3K is located in exon 6 with diabetic nephropathy progression. PMID: 23492569
5. two new mutations and additional variants within the FN3K gene in diabetic patients PMID: 21288167
6. These findings suggest that deglycating enzymes Glyoxalase I and fructosamine-3-kinase may be involved in the malignant transformation of colon mucosa. PMID: 21253391
7. G900C polymorphism associates with the level of HbA (1c) and the onset of type 2 diabetes mellitus, but not with either of the diabetic microvascular complications. PMID: 19834870
8. involved in the removal of fructosamine residues from hemoglobin in erythrocytes. PMID: 11975663
9. The aim of this work was to identify the fructosamine residues on hemoglobin that are removed as a result of the action of FN3K in intact erythrocytes. PMID: 15102834
10. These data suggest that FN3K and FN3KRP act as protein repair enzymes and are expressed constitutively in human cells independently of some of the variables altered in the diabetic state. PMID: 15381090
11. Enzyme is a constitutive "housekeeping" gene and that ig plays an important role in cell metabolism, possibly as a deglycating enzyme. PMID: 16037310
12. No significant correlation between FN3K activity and the levels of HbA1c, total glycated haemoglobin (GHb) and haemoglobin fructoselysine residues, either in the normoglycaemic or diabetic group. PMID: 16523184
13. In this paper we propose a resolution of both these quandaries by proposing that fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by FN3KRP and/or possibly FN3K. PMID: 16920277

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HGNC: 24822

OMIM: 608425

KEGG: hsa:64122

STRING: 9606.ENSP00000300784

UniGene: Hs.151135