Growth arrest specific protein 8 antibody; MGC138326 antibody; GAS 11 antibody; GAS 8 antibody; GAS-11 antibody; GAS-8 antibody; GAS11 antibody; Gas8 antibody; GAS8_HUMAN antibody; Growth arrest specific 11 antibody; Growth arrest specific 8 antibody; Growth arrest specific protein 11 antibody; Growth arrest-specific protein 11 antibody; Growth arrest-specific protein 8 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human GAS8
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
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Lead Time
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Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner.
Gene References into Functions
In papillary thyroid carcinoma (PTC) cell lines, GAS8-AS1 inhibited proliferation, activated autophagy, and increased ATG5 expression. Downregulation of ATG5 reversed GAS8-AS1-mediated activation of autophagy leading to cell death, revealing a novel mechanism of the GAS8-AS1-ATG5 axis in PTC cell lines. PMID: 29327301
Study identifies bi-allelic loss-of-function mutations in GAS8 as a cause for primary ciliary dyskinesia, and unveils the key importance of the protein encoded by this gene in N-DRC integrity and in the proper alignment of axonemal microtubules in humans. PMID: 27120127
Here, we generate the first mouse with a Gas8 mutation and show that it causes severe Primary Ciliary Dyskinesia (PCD)phenotypes; however, there were no overt Hh pathway phenotypes. In addition, we identified two human patients with missense variants in Gas8 PMID: 27472056
Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. PMID: 26387594
A two-hybrid screen for proteins that interact with NS1 from influenza A yielded growth arrest-specific protein 8. Gas8 associated with NS1 in vitro and in vivo. PMID: 19995461
Expressed in respiratory epithelial cells (at protein level). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney.