GFM2 Antibody

Code CSB-PA856889ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA856889ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA856889ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GFM2 Polyclonal antibody
Uniprot No.
Target Names
GFM2
Alternative Names
GFM2 antibody; EFG2 antibody; MSTP027 antibody; Ribosome-releasing factor 2 antibody; mitochondrial antibody; RRF2mt antibody; Elongation factor G 2 antibody; mitochondrial antibody; EF-G2mt antibody; mEF-G 2 antibody; Elongation factor G2 antibody; hEFG2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ribosome-releasing factor 2, mitochondrial protein (520-779AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
Gene References into Functions
  1. GFM2 mutations could be causative of a phenotype of Leigh syndrome with arthrogryposis multiplex congenita. PMID: 26016410
  2. These findings constitute the first reported phenotype associated with SNPs in the EF-G2mt gene and implicate the human EF-G2mt gene as a pharmacogenetic candidate gene for statin toxicity in humans PMID: 22719265
  3. Myoblasts isolated from the MELAS patients show A3243G mutation in tRNALeu(UUR) produces a severe respiratory chain deficiency and this phenotype can be partially suppressed by overexpression of EFTu and EFG2. PMID: 18753147
  4. EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. PMID: 19716793
Subcellular Location
Mitochondrion.
Protein Families
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
Tissue Specificity
Widely expressed.
Database Links

HGNC: 29682

OMIM: 606544

KEGG: hsa:84340

STRING: 9606.ENSP00000296805

UniGene: Hs.277154

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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