GIMAP5 Antibody

1. GIMAP5 loss-of-function mutation results in T cell deficiencies. PMID: 29382851
2. These data,demonstrating the downregulation of the mRNA and protein expression levels of GIMAP5 and GIMAP6 in the tumor tissues and blood of patients with HCC, suggested the involvement of GIMAP5 and GIMAP6 in the pathogenesis of HCC, and indicate their possible use as diagnostic markers for HCC. PMID: 27667392
3. gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut [review] PMID: 25944983
4. Data indicate that overexpression of GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) in HEK (human embryonic kidney)-293 cells resulted in increased Ca2+ accumulation within the mitochondria. PMID: 23098229
5. Notch signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5. PMID: 20817506
6. These data establish Gimap5 as a key regulator of hematopoietic integrity and lymphocyte homeostasis PMID: 20190135
7. A significant increase in systemic lupus erythematosus risk associated with the most common GIMAP5 haplotype was found (odds ratio 1.26, 95% CI 1.02 to 1.54, p = 0.0033). PMID: 17220214
8. Resutls show that Gimap5 is located in the endoplasmic reticulum, and the endogenous Gimap5 mRNA is up-regulated in activated T-cells. PMID: 17369194
9. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same single nucleotide polymorphism in another autoimmune disease. PMID: 17641683
10. Data show that IAN5 polymorphisms are associated with susceptibility to Systemic lupus erythematosus and the development of clinical disease manifestations in a strictly Korean population. PMID: 19762377

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HGNC: 18005

OMIM: 608086

KEGG: hsa:55340

STRING: 9606.ENSP00000351473

UniGene: Hs.647079