GINS4 Antibody

Code CSB-PA009433GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GINS4
Alternative Names
DNA replication complex GINS protein SLD5 antibody; GINS complex subunit 4 (Sld5 homolog) antibody; GINS complex subunit 4 antibody; GINS4 antibody; SLD5 antibody; SLD5 homolog antibody; SLD5 S cerevisiae homolog of antibody; SLD5_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SLD5
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.
Gene References into Functions
  1. Knockdown of SLD5 using small interfering RNA resulted in reduction of cell growth both in vitro and an in vivo xenograft model. Moreover, we found that high levels of SLD5 in bladder cancer cells result from downregulation of microRNA (miR)-370 that otherwise suppresses its expression. PMID: 27499248
  2. Sld5 a component of GINS complex interacts with SIK1 and recruits it to the sites of DNA replication at the onset of S phase. PMID: 27592030
  3. The C-terminal domains of the Sld5 and Psf1 subunits are connected by linker regions to the core complex, and the C-terminal domain of Sld5 is important for core complex assembly. PMID: 17417653
Subcellular Location
Nucleus. Chromosome. Cytoplasm.
Protein Families
GINS4/SLD5 family
Database Links

HGNC: 28226

OMIM: 610611

KEGG: hsa:84296

STRING: 9606.ENSP00000276533

UniGene: Hs.656996

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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