GPN1 Antibody

1. Results show that Gpn1-inhibitable, nuclear polyubiquitination on lysine 216 regulates the half-life of Gpn3 by tagging it for proteasomal degradation. PMID: 29029378
2. an acquired PDZ-binding motif in Gpn3 Q279* caused Gpn3 nuclear entry, and inhibited Gpn1 nuclear export and Gpn3-mediated RNAPII nuclear targeting. PMID: 28940195
3. GPN1 gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
4. Gpn1-Gpn3 interaction was essential to maintain steady-state protein levels of both GTPases PMID: 25241168
5. A highly active, evolutionarily conserved nuclear export sequences in XAB1/Gpn1, was identified. PMID: 22796641
6. Data show that GPN1/GPN3 define a new family of small GTPases that are specialized for the transport of RNA polymerase II into the nucleus. PMID: 21768307
7. RPAP4/GPN1 is a member of a newly discovered GTPase family that contains a highly conserved GPN loop motif that is essential, along with its GTP-binding motifs, for nuclear localization of POLR2A/RPB1 in a process that also requires microtubule assembly PMID: 20855544
8. relieves MBD2-mediated transcriptional repression and reactivates transcription from methylated promoters PMID: 12588985

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HGNC: 17030

OMIM: 611479

KEGG: hsa:11321

STRING: 9606.ENSP00000264718

UniGene: Hs.18259