GTF2H1 Antibody

1. Data suggest that a common TFIIH subunit p62 recruitment mechanism is shared by UV-stimulated scaffold protein A (UVSSA) in transcription-coupled repair (TCR) and xeroderma pigmentosum, complementation group C protein (XPC) in global genome repair (GGR). PMID: 29069470
2. Here, the authors show that an acidic region of DP1, whose function has remained elusive, binds to the plekstrin homology (PH) domain of the p62 subunit of TFIIH that contributes to transcriptional activation. PMID: 27825926
3. Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH. PMID: 24403578
4. These data suggest that the RVFV NSs protein is able to interact with the TFIIH subunit p62 inside infected cells and promotes its degradation, which can occur directly in the nucleus. PMID: 21543505
5. cdk1 phosphorylates p62 in vitro and in vivo at T269 and S272, which is necessary for the maintenance of appropriate cyclin B1 levels and the levels of cdk1 activity necessary to allow cells to properly enter and exit mitosis. PMID: 20974803
6. transcription factor b3, previously identified as a component of the transcription factor IIH core complex, is shown instead to be transcription factor b4 PMID: 14500720
7. p62 subunit of TFIIH interacts with TRbeta in a ligand-dependent manner. PMID: 15625236
8. The pleckstrin homology domain from the 62 kDa subunit Tfb1 (residues 1-108) of TFIIH is sufficient for binding to the activation domain of herpes simplex virus protein VP16. PMID: 15909982
9. GTF2H1 polymorphisms/haplotypes may contribute to genetic susceptibility to lung cancer. PMID: 18692935

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HGNC: 4655

OMIM: 189972

KEGG: hsa:2965

STRING: 9606.ENSP00000265963

UniGene: Hs.577202