HACL1 Antibody

Code CSB-PA010116GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
HACL1
Alternative Names
1600020H07Rik antibody; 2 HPCL antibody; 2 hydroxyacyl CoA lyase 1 antibody; 2 hydroxyphytanoyl CoA lyase antibody; 2-HPCL antibody; 2-hydroxyacyl-CoA lyase 1 antibody; 2-hydroxyphytanoyl-CoA lyase antibody; FLJ55041 antibody; Hacl1 antibody; HACL1_HUMAN antibody; HPCL antibody; HPCL2 antibody; HSPC279 antibody; PHYH2 antibody; Phytanoyl CoA 2 hydroxylase 2 antibody; Phytanoyl CoA hydroxylase 2 antibody; Phytanoyl-CoA 2-hydroxylase 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human HACL1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids. Plays a significant role in the biosynthesis of heptadecanal in the liver.
Gene References into Functions
  1. Data show that a easy assay for 2-hydroxyacyl-CoA lyase (HACL1) and sphingosine-1-phosphate lyase (SGPL1) activities was developed. PMID: 24323699
  2. Transport of thiamine pyrophosphate into peroxisomes is dependent on HACL1 import, without requirement of a specific solute transporter. PMID: 21708296
  3. 2-hydroxyphytanoyl-CoA lyase has a role in the breakdown of long chain 2-hydroxyfatty acids PMID: 15644336
  4. peroxisomal thiamine-pyrophosphate depending enzyme required for the degradation of phytanic acid, catalyzing the cleavage of 2-hydroxyphytanoyl-CoA lyase into formyl-CoA and pristanal PMID: 10468558
Subcellular Location
Peroxisome.
Protein Families
TPP enzyme family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 17856

OMIM: 604300

KEGG: hsa:26061

STRING: 9606.ENSP00000323811

UniGene: Hs.63290

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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