HSPB11 Antibody

Code CSB-PA010834GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
HSPB11
Alternative Names
Chromosome 1 open reading frame 41 antibody; Heat shock protein beta-11 antibody; HSB11_HUMAN antibody; Hspb11 antibody; HSPCO34 antibody; IFT25 antibody; Placental protein 25 antibody; PP25 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human HSPB11
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation.
Gene References into Functions
  1. HSPB11 was identified as a novel prognostic marker in patients with high-grade glioma. PMID: 26544773
  2. HSPB11 are induced during multiple sclerosis lesion development in white but not grey matter. PMID: 26694816
  3. These data suggest that Hsp16.2 can prevent the destabilization of mitochondrial membrane systems and could represent a suitable target for modulating cell death pathways. PMID: 17275951
  4. Hsp16.2 expression is directly correlated with the histological grade of brain tumors. PMID: 18154656
Subcellular Location
Cell projection, cilium.
Protein Families
IFT25 family
Tissue Specificity
Detected in placenta.
Database Links

HGNC: 25019

KEGG: hsa:51668

STRING: 9606.ENSP00000194214

UniGene: Hs.525462

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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