ICE1 Antibody

Code CSB-PA897466LA01HU
Size US$166
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Image
  • IHC image of CSB-PA897466LA01HU diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • Immunofluorescence staining of Hela cell with CSB-PA897466LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • Immunofluorescence staining of A549 cell with CSB-PA897466LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ICE1 Polyclonal antibody
Uniprot No.
Target Names
ICE1
Alternative Names
K0947_HUMAN antibody; KIAA0947 antibody; Uncharacterized protein KIAA0947 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Little elongation complex subunit 1 protein (1213-1505AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ICE1 Antibody (Product code: CSB-PA897466LA01HU) is Non-conjugated. For ICE1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA897466LB01HU ICE1 Antibody, HRP conjugated ELISA
FITC CSB-PA897466LC01HU ICE1 Antibody, FITC conjugated
Biotin CSB-PA897466LD01HU ICE1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies.
Gene References into Functions
  1. The results indicate that p53 interferes with the interaction between ELL/EAF and ICE1 and represses transcription of small nuclear RNA genes by Pol II. PMID: 27268141
  2. Multigenerational autosomal dominant inheritance of 5p chromosomal deletions resulting in Cri-du-Chat Syndrome with SEMA5A, CTNND2, and ICE1 deficiencies has been described. PMID: 26601658
Subcellular Location
Nucleus. Nucleus, Cajal body.
Protein Families
ICE1 family
Database Links

HGNC: 29154

KEGG: hsa:23379

STRING: 9606.ENSP00000296564

UniGene: Hs.449296

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