KBTBD7 Antibody

Code CSB-PA823893ESR1HU
Size US$166
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  • Western blot
    All lanes: KBTBD7 antibody at 1.85μg/ml
    Lane 1: HL60 whole cell lysate
    Lane 2: A549 whole cell lysate
    Lane 3: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 77 kDa
    Observed band size: 77 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA823893ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA823893ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KBTBD7 Polyclonal antibody
Uniprot No.
Target Names
KBTBD7
Alternative Names
1110008P08Rik antibody; AU045792 antibody; DKFZP434E2318 antibody; Gm295 antibody; KBTB7_HUMAN antibody; KBTBD 7 antibody; KBTBD7 antibody; Kelch repeat and BTB (POZ) domain containing 7 antibody; Kelch repeat and BTB domain containing protein 7 antibody; Kelch repeat and BTB domain-containing protein 7 antibody; OTTHUMP00000018313 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Kelch repeat and BTB domain-containing protein 7 protein (475-684AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex.
Gene References into Functions
  1. KBTBD6 and KBTBD7 specifically bind to GABARAP proteins.KBTBD6 and KBTBD7 form a heterodimeric CRL3 complex. PMID: 25684205
  2. KBTBD7 proteins may act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. PMID: 20132730
Subcellular Location
Cytoplasm. Nucleus.
Database Links

HGNC: 25266

OMIM: 617739

KEGG: hsa:84078

STRING: 9606.ENSP00000368797

UniGene: Hs.594902

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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