KCTD12 Antibody

1. KCTD12 may exert its inhibitory role in ESCC through the suppression of WNT /NOTCH, stem cell factors, and chromatin remodelers and can be introduced as an efficient therapeutic marker. PMID: 30157793
2. our study demonstrate that KCTD12 binds to CDC25B and activates CDK1 and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates KCTD12 at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTD12. Thus, the KCTD12-CDC25B-CDK1-Aurora A axis has important implications for cancer diagnoses and prognoses. PMID: 28869606
3. Low KCTD12 expression is associated with uveal melanoma. PMID: 28000887
4. Studies determined that KCTD12 plays an important role in the tumorigenesis of colorectal cancer progression via activation of the ERK signaling pathway. PMID: 26847701
5. N-terminal domain of KCTD12 assumes an alpha/beta structure, whereas the C-terminal domain is predominantly characterized by a beta-structure. PMID: 23996491
6. KCTD12 is a useful and reliable biomarker for both the diagnosis and prognosis of gastrointestinal stromal tumor. PMID: 23290008
7. This study provided that kctd12 are associated with Bipolar I in the Han Chinese population. PMID: 20386566
8. novel human gene, designated PFET1 (predominantly fetal expressed T1 domain) present in a variety of fetal organs, with highest expression levels in the cochlea and brain PMID: 15357420
9. Pfetin is a powerful prognostic marker for gastrointestinal stromal tumors. PMID: 18347171

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HGNC: 14678

OMIM: 610521

KEGG: hsa:115207

STRING: 9606.ENSP00000317141

UniGene: Hs.644125