KLHL2 Antibody

Datasheet

Code	CSB-PA012421LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Jurkat whole cell lysate, Mouse liver tissue All lanes: KLHL2 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 66, 67, 57 kDa Observed band size: 66, 67 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA012421LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA012421LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KLHL2 Polyclonal antibody

Uniprot No.

O95198

Target Names

KLHL2

Alternative Names

ABP KELCH antibody; Actin binding protein Mayven antibody; Actin-binding protein Mayven antibody; kelch antibody; kelch like 2 antibody; Kelch like 2, Mayven antibody; Kelch like family member 2 antibody; Kelch like protein 2 antibody; Kelch-like protein 2 antibody; KLHL2 antibody; KLHL2_HUMAN antibody; MAV antibody; MAYVEN antibody; OTTHUMP00000219997 antibody; OTTHUMP00000219998 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Kelch-like protein 2 protein (1-155AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The KLHL2 Antibody (Product code: CSB-PA012421LA01HU) is Non-conjugated. For KLHL2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA012421LB01HU	KLHL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA012421LC01HU	KLHL2 Antibody, FITC conjugated
Biotin	CSB-PA012421LD01HU	KLHL2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.

Gene References into Functions

Co-expression of KLHL2 and Cullin3 decreases the abundance of WNK1, WNK3 and WNK4 within HEK293T cells. PMID: 23838290
Results suggest a novel E3 ubiquitin ligase function of KLHL2, with NPCD as a substrate. PMID: 21549840
overexpression of Mayven may promote tumor growth through c-Jun and cyclin D1 PMID: 15735724

Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol.

Tissue Specificity

Ubiquitous. Detected throughout the brain.

Database Links

HGNC: 6353

OMIM: 605774

KEGG: hsa:11275

STRING: 9606.ENSP00000424198

UniGene: Hs.388668

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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