KLHL2 Antibody

Code CSB-PA012421LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Jurkat whole cell lysate, Mouse liver tissue
    All lanes: KLHL2 antibody at 3µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 66, 67, 57 kDa
    Observed band size: 66, 67 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA012421LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA012421LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KLHL2 Polyclonal antibody
Uniprot No.
Target Names
KLHL2
Alternative Names
ABP KELCH antibody; Actin binding protein Mayven antibody; Actin-binding protein Mayven antibody; kelch antibody; kelch like 2 antibody; Kelch like 2, Mayven antibody; Kelch like family member 2 antibody; Kelch like protein 2 antibody; Kelch-like protein 2 antibody; KLHL2 antibody; KLHL2_HUMAN antibody; MAV antibody; MAYVEN antibody; OTTHUMP00000219997 antibody; OTTHUMP00000219998 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Kelch-like protein 2 protein (1-155AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The KLHL2 Antibody (Product code: CSB-PA012421LA01HU) is Non-conjugated. For KLHL2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA012421LB01HU KLHL2 Antibody, HRP conjugated ELISA
FITC CSB-PA012421LC01HU KLHL2 Antibody, FITC conjugated
Biotin CSB-PA012421LD01HU KLHL2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Gene References into Functions
  1. Co-expression of KLHL2 and Cullin3 decreases the abundance of WNK1, WNK3 and WNK4 within HEK293T cells. PMID: 23838290
  2. Results suggest a novel E3 ubiquitin ligase function of KLHL2, with NPCD as a substrate. PMID: 21549840
  3. overexpression of Mayven may promote tumor growth through c-Jun and cyclin D1 PMID: 15735724
Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol.
Tissue Specificity
Ubiquitous. Detected throughout the brain.
Database Links

HGNC: 6353

OMIM: 605774

KEGG: hsa:11275

STRING: 9606.ENSP00000424198

UniGene: Hs.388668

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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