LIMA1 Antibody

1. this study identifies LIMA1 as a key protein regulating intestinal cholesterol absorption. PMID: 29880681
2. Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. Authors therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy. PMID: 28465438
3. Data provide evidence that downregulation of EPLIN-alpha may be associated with poor prognosis for patients with epithelial ovarian cancer (EOC), and that this molecule appears to play a tumour suppressor role by inhibition of EOC growth and migration. PMID: 27035883
4. EPLIN is functionally linked to molecules like actin and paxillin and has been implicated in a number of potential pathways to enhance metastatic potential PMID: 26350886
5. a major activity of DNp73 is to establish initiation of the invasion-metastasis cascade via EPLIN-dependent IGF1R regulation PMID: 24135282
6. EGF promotes epithelial-mesenchymal transition and induces degradation of EPLIN, a putative suppressor of prostate cancer metastasis. PMID: 23188829
7. Together with the findings that EPLIN-alpha inhibits cellular growth and invasion, we conclude that EPLIN-alpha is a tumour suppressor of oesophageal cancer PMID: 22493360
8. EPLIN clutch is necessary for stabilization of capillary structures in an angiogenesis model. PMID: 22194609
9. EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis. PMID: 21625216
10. EPLINalpha over-expression can regulate HECV cell motility, matrix adhesion and tubule formation in vitro and slow in vivo tumour formation, suggesting an anti-angiogenic role for EPLINalpha. PMID: 20848180
11. EPLIN functions to link the cadherin-catenin complex to F-actin and simultaneously stabilizes this population of actin fibers, resulting in the establishment of the adhesion PMID: 18093941
12. expression of EPLIN-alpha in breast cancer is down-regulated in breast cancer cells . PMID: 18796137
13. EPLIN protein may function during cytokinesis to maintain local accumulation of key cytokinesis proteins at the furrow. PMID: 19221476

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HGNC: 24636

OMIM: 608364

KEGG: hsa:51474

STRING: 9606.ENSP00000378400

UniGene: Hs.525419