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Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Gene References into Functions
Two mutants of LIPH lead to secretion defects of LIPH, which are involved in the pathogenesis of Autosomal recessive woolly hair/hypotrichosis. PMID: 29346610
Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in three consanguineous Pakistani families. PMID: 28425126
The present study shows 93% of Japanese patients with ARWH had at least one of the two founder mutations in exon 6 of LIPH. Highly prevalent founder mutations in LIPH. PMID: 27641630
The authors report no apparent decrease in total hair count but remarkable miniaturization and increased telogen/anagen hair ratio in patients homozygous mutations in LIPH. PMID: 27375176
This meta-analysis demonstrates that the T allele in the LIPC rs493258 polymorphism was significantly associated with the risk of any and late age related macular degeneration PMID: 27763569
Our data suggest that LIPH may have prognostic value for esophageal cancer. PMID: 26341494
sequencing LIPH identi fi ed a novel non-sense mutation (c.328C>T; p.Arg110*) in one and a previously reported 2-bp deletion mutation (c.659_660delTA, p.Ile220ArgfsX29) in three other families. PMID: 24628704
A heterozygous missense mutation c.736T>A (p.Cys246Ser) in exon 6 of the LIPH gene of both the affected individuals was identified. In addition, we also found that both patients carried heterozygous sequences in exon 5 of the LIPH gene. PMID: 25899282
The study further extends the body of evidence that sequence variants in the LIPH gene result in hypotrichosis and woolly hair phenotype. PMID: 26645693
c.460_461AG>GA (p.Ser154Asp) in exon 3 and c.742C>A (p.His248Asn) in exon 6 associated with autosomal recessive woolly hair PMID: 25201209
High LIPH expression is associated with metastasis in breast cancer. PMID: 25123262
Mutation patterns of LIPH might be associated with hypotrichosis severity in autosomal recessive woolly hair/hypotrichosis. PMID: 24586639
Immunohistochemistry detected LIPH expression in most of the adenocarcinomas and bronchioloalveolar carcinomas obtained from lung cancer patients. LIPH expression was also observed less frequently in the squamous lung cancer tissue samples. PMID: 24380866
Among South Indian subjects without diabetes, the rs1800588 C/T (C-480T) and rs6074 C/A (Thr479Thr) variants of the HL gene are associated with hypertriglyceridemia and low HDL-C, respectively. The TGC haplotype was significantly associated with low HDL-C PMID: 23550552
A case of Japanese siblings with autosomal recessive woolly hair associated with LIPH gene homozygous mutation of c.736T > A is presented. PMID: 23590372
analysis of the LIPH gene revealed homozygosity for a novel truncating mutation, as well as three previously identified mutations in affected individuals with autosomal recessive hypotrichosis and woolly hair. PMID: 23066499
The beta9 loop domain of PA-PLA1alpha has a crucial role in autosomal recessive woolly hair/hypotrichosis [case report] PMID: 22475755
the c.659_660delTA mutation in the LIPH gene caused autosomal recessive wooly hair/hypotrichosis phenotype in the studied family. PMID: 22125978
736T>A transition is highly specific and common in autosomal recessive woolly hair/hypotrichosis of Japanese origin. PMID: 21352330
A phosphatidic acid-phospholipase A1alpha-lysophosphatidic acid-P2Y5 axis regulates differentiation of hair follicles via a tumour necrosis factor alpha converting enzyme-transforming growth factor alpha-epidermal growth factor receptor pathway. PMID: 21857648
Mutations identified in the present study extend the body of evidence implicating LPAR6 and LIPH genes in pathogenesis of human hereditary hair loss. PMID: 21426374
The results suggest defective activation of P2Y5 due to reduced 2-acyl lysophosphatidic acid production by the mutant PA-PLA1a that are encoded by LIPH is involved in the pathogenesis of ARH. PMID: 20213768
Studied five consanguineous Pakistani families with autosomal recessive hypotrichosis and identified a novel splice site and two previously reported mutations in the LIPH gene. PMID: 20107739
these findings not only expand the spectrum of LIPH mutations, but also provide a better understanding of the crucial role of the LIPH/LPA/P2Y5 signaling in hair growth in humans. PMID: 19892526
PA-selective PLA(1) has a role in LPA production. PMID: 12063250
mRNA expressed in intestine, lung, and pancreas. Lipase H protein was also detected in human intestine. PMID: 12213196
individuals with an inherited form of hair loss and a hair growth defect were homozygous for a deletion in the LIPH gene on chromosome 3q27; results suggest that lipase H participates in hair growth and development PMID: 17095700
identification of a novel deletion mutation in exon 2 of LIPH gene in a Pakistani family with autosomal recessive hypotrichosis PMID: 17333281
a novel deletion mutation in exon 5 (c.659-660delTA) causing frameshift and downstream premature termination codon causes autosomal recessive hypotrichosis (LAH2) PMID: 18445047
The deletion mutation (c.682delT) reported lies between beta9 and lid loops and changes the reading frame after 31 amino acids, thereby eliminating the lid peptide sequence required for substrate recognition in combination with beta9 loop. PMID: 18795930
gene duplication mutation in exon 2 was found to segregate with hypotrichosis in consanguineous and distantly related Izraeli families PMID: 18820939
LIPH is a second causative gene for ARWH/hypotrichosis, giving rise to a phenotype clinically indistinguishable from P2RY5 mutations PMID: 18830268
The mutations reported here are the first missense mutations identified in the LIPH gene, which extend the body of evidences implicating the LIPH gene in the pathogenesis of human hereditary hair loss. PMID: 19167195
crucial role of LIPH gene in hair growth. PMID: 19262606
Our study increases the spectrum of known LIPH mutations and provides biochemical evidence for the important role of lipase H and its product LPA in human hair growth PMID: 19536142
Mutations in LIPH result in variable degrees of hypotrichosis simplex, woolly hair is an essential component of the clinical spectrum;hot spot in the LIPH gene may be c.280_369dup in exon 2 PMID: 19766349
Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently expressed in hair follicles, including th