LRSAM1 Antibody

Code CSB-PA751010ESR1HU
Size US$166
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  • Western blot
    All lanes: LRSAM1 antibody at 2.57µg/ml
    Lane 1: Mouse brain tissue
    Lane 2: Jurkat whole cell lysate
    Lane 3: Hela whole cell lysate
    Lane 4: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 84, 81, 36 kDa
    Observed band size: 84 kDa

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA751010ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LRSAM1 Polyclonal antibody
Uniprot No.
Target Names
LRSAM1
Alternative Names
CMT2P antibody; E3 ubiquitin protein ligase LRSAM1 antibody; E3 ubiquitin-protein ligase LRSAM1 antibody; EC 6.3.2.- antibody; FLJ31641 antibody; hTAL antibody; Leucine rich repeat and sterile alpha motif containing 1 antibody; Leucine rich repeat and sterile alpha motif containing protein 1 antibody; Leucine-rich repeat and sterile alpha motif-containing protein 1 antibody; LRSAM1 antibody; LRSM1_HUMAN antibody; OTTHUMP00000022174 antibody; OTTHUMP00000022175 antibody; RIFLE antibody; TAL antibody; Tsg101 associated ligase antibody; Tsg101-associated ligase antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human E3 ubiquitin-protein ligase LRSAM1 protein (1-290AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy).
Gene References into Functions
  1. We identified a novel LRSAM1 missense mutation (c.2120C > T, p.Pro707Leu) mapping to the RING domain. The identified missense mutation, as well as of another recently reported pathogenic missense mutation (c.2081G > A, p.Cys694Tyr), revealed that in vitro ubiquitylation activity was largely abrogated. PMID: 28335037
  2. findings suggest that the mutant LRSAM1 may aberrantly affect the formation of transcription machinery. PMID: 27615052
  3. findings demonstrate that the isolated genetic entity Charcot-Marie-Tooth type 2G is caused by a missense mutation in LRSAM1. PMID: 27686364
  4. LRSAM1 exhibited self-association in vitro and in vivo. The study found the self-association of LRSAM1 promotes intermolecular ubiquitination and proved a potential N-terminal ubiquitination. PMID: 28189685
  5. disruption of the C-terminal RING domain confers dominant negative properties to LRSAM1 PMID: 24894446
  6. Our data further confirms that LRSAM1 mutations are associated with CMT2 of AD inheritance. PMID: 22781092
  7. Authors identify LRSAM1 as the E3 ligase responsible for anti-Salmonella autophagy-associated ubiquitination. PMID: 23245322
  8. homozygous mutation in LRSAM1 was proposed as a strong candidate for the disease in a family with recessive axonal polyneuropathy PMID: 22012984
  9. LRSAM1 as a component of the antibacterial autophagic response. PMID: 20616063
  10. LRSAM1 is a strong candidate for the causal gene for the Charcot-Marie-Tooth disease. PMID: 20865121
  11. Results suggest that RIFLE represents a novel signaling protein that mediates components of the Wnt/wingless signaling pathway and cell adhesion in PC12 cells [RIFLE protein]. PMID: 14635195
  12. Tal regulates a Tsg101-associated complex responsible for the sorting of cargo into cytoplasm-containing vesicles that bud at the multivesicular body and at the plasma membrane PMID: 15256501
  13. Tal polyubiquitinates lysine residues in the C-terminus of uncomplexed Tsg101, resulting in proteasomal degradation. PMID: 18077552

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Involvement in disease
Charcot-Marie-Tooth disease 2P (CMT2P)
Subcellular Location
Cytoplasm.
Tissue Specificity
Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.
Database Links

HGNC: 25135

OMIM: 610933

KEGG: hsa:90678

STRING: 9606.ENSP00000300417

UniGene: Hs.495188

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