MAPKBP1 Antibody

Code CSB-PA013476GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
MAPKBP1
Alternative Names
JNK binding protein 1 antibody; JNK-binding protein 1 antibody; JNKBP-1 antibody; JNKBP1 antibody; KIAA0596 antibody; MABP1_HUMAN antibody; MAPKBP 1 antibody; mapkbp1 antibody; Mitogen activated protein kinase binding protein 1 antibody; Mitogen-activated protein kinase-binding protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human MAPKBP1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway.
Gene References into Functions
  1. We identified mutations in MAPKBP1 as a genetic cause of juvenile or late-onset and cilia-independent nephronophthisis. PMID: 28089251
  2. JNKBP1 and NOD2 are co-expressed in the human intestinal epithelium and in immune cells recruited in the lamina propria, which suggests that JNKBP1 contributes to maintain NOD2-mediated intestinal immune homeostasis. PMID: 22700971
Involvement in disease
Nephronophthisis 20 (NPHP20)
Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole.
Tissue Specificity
Expressed in intestinal mucosa, where it is detected in epithelial cells, endothelial cells, smooth muscle cells and immune cells, such as lymphocytes. Expressed in kidney.
Database Links

HGNC: 29536

OMIM: 616786

KEGG: hsa:23005

STRING: 9606.ENSP00000393099

UniGene: Hs.513661

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