MARC1 Antibody

Datasheet

Code	CSB-PA898405
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA898405(MARC1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA898405(MARC1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: CSB-PA898405(MARC1 Antibody) at dilution 1/1400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

Q5VT66

Target Names

MARC1

Alternative Names

MTARC1 antibody; MARC1 antibody; MOSC1Mitochondrial amidoxime-reducing component 1 antibody; mARC1 antibody; EC 1.7.-.- antibody; Molybdenum cofactor sulfurase C-terminal domain-containing protein 1 antibody; MOSC domain-containing protein 1 antibody; Moco sulfurase C-terminal domain-containing protein 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human MARC1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.

Gene References into Functions

The transmembrane domain of mARC1 shown to be sufficient for mitochondrial targeting and the N-terminal targeting signal to function as a supportive receptor for the outer mitochondrial membrane. PMID: 23086957
results provide the first hints that mARC might be involved in mitochondrial N(omega)-hydroxy-L-arginine reduction and could be of physiological significance in affecting endogenous nitric oxide levels PMID: 21029045
molybdoprotein mARC1 is involved in the activation of N-hydroxylated prodrugs. PMID: 19053771

Subcellular Location

Mitochondrion outer membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP.

Database Links

HGNC: 26189

OMIM: 614126

KEGG: hsa:64757

STRING: 9606.ENSP00000355877

UniGene: Hs.497816

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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