MATN2 Antibody, Biotin conjugated

Code CSB-PA013521LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MATN2 Polyclonal antibody
Uniprot No.
Target Names
MATN2
Alternative Names
Crtm2 antibody; MATN 2 antibody; Matn2 antibody; MATN2_HUMAN antibody; Matrilin-2 antibody; Matrilin2 antibody; MGC102477 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Matrilin-2 protein (746-867AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Involved in matrix assembly.
Gene References into Functions
  1. findings showed that YopK binds to the cell surface-exposed endogenous MATN2 and that purified YopK protein strongly inhibits the bacterial adherence to HeLa cells PMID: 28533472
  2. Data show that the mRNA and protein levels of matrilin-2 were increased after irradiation treatment in both mouse lung tissue and human pulmonary alveolar epithelial cells (HPAEpiC). PMID: 27923659
  3. Taken together, our results showed that high-glucose-induced Matrilin-2 expression that was mediated by the TGF-beta1/Smad3 signaling pathway might play a role in Diabetic nephropathy (DN) pathogenesis and our finding provided a potential diagnostic and/or therapeutic target for DN. PMID: 27105914
  4. Matrilin-2 induces post-burn inflammatory responses as an endogenous danger signal, partly through a TLR4-mediated mechanism PMID: 26271809
  5. matrilin-2, a filament-forming protein widely distributed in extracellular matrices. PMID: 11852232
  6. matrilin-2 is expressed in normal skin by keratinocytes and fibroblasts and may thus contribute to cutaneous homeostasis. PMID: 12164922
  7. study of interactions by which matrilin-2 can be integrated into extracellular filamentous networks PMID: 12180907
  8. These results suggest that matrilin-2 may be a specific and clinically useful biomarker for discriminating between indolent and clinically aggressive pilocytic astrocytoma. PMID: 16401863
  9. DeltaNp63/BMP-7 signaling pathway modulates wound healing process through the regulation of matrilin-2. PMID: 18328806
  10. data indicate matrilin-2 is a novel basement membrane component in the liver, synthesized during sinusoidal "capillarization" in cirrhosis & in hepatocellular carcinoma PMID: 18386166

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Subcellular Location
Secreted.
Database Links

HGNC: 6908

OMIM: 602108

KEGG: hsa:4147

STRING: 9606.ENSP00000430487

UniGene: Hs.189445

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