MED17 Antibody

Datasheet

Code	CSB-PA865147LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse heart tissue, Mouse kidney tissue All lanes: MED17 antibody at 2.8μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 73, 16 kDa Observed band size: 73 kDa Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA865147LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MED17 Polyclonal antibody

Uniprot No.

Q9NVC6

Target Names

MED17

Alternative Names

77-KD subunit antibody; Activator recruited cofactor 77 kDa component antibody; Activator-recruited cofactor 77 kDa component antibody; ARC77 antibody; Cofactor required for Sp1 transcriptional activation subunit 6 antibody; cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa antibody; CRSP complex subunit 6 antibody; CRSP6 antibody; CRSP77 antibody; DRIP80 antibody; med17 antibody; MED17_HUMAN antibody; Mediator complex subunit 17 antibody; Mediator of RNA polymerase II transcription subunit 17 antibody; Mediator of RNA polymerase II transcription subunit 17, S cerevisiae, homolog of antibody; Thyroid hormone receptor-associated protein complex 80 kDa component antibody; Thyroid hormone receptor-associated protein, 80-KD subunit antibody; Transcriptional coactivator CRSP77 antibody; Trap80 antibody; VITAMIN D RECEPTOR-INTERACTING PROTEIN, 80-KD antibody; Vitamin D3 receptor-interacting protein complex 80 kDa component antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Mediator of RNA polymerase II transcription subunit 17 protein (411-651AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MED17 Antibody (Product code: CSB-PA865147LA01HU) is Non-conjugated. For MED17 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA865147LB01HU	MED17 Antibody, HRP conjugated	ELISA
FITC	CSB-PA865147LC01HU	MED17 Antibody, FITC conjugated
Biotin	CSB-PA865147LD01HU	MED17 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene References into Functions

These findings suggest that hMED17 may play essential roles in switching between transcription and nucleotide excision repair. PMID: 25482373
TRAP80 is a selective regulator of hepatic lipogenesis and is required for LXR-dependent SREBP-1c activation. PMID: 25437875
Studies indicate that the activation domain of p53 (p53AD) binds directly to the MED17 subunit of Mediator, whereas the p53 C-terminal domain (p53CTD) binds the MED1 subunit. PMID: 21326907
the p. L371P mutation in MED17 is a founder mutation in the Caucasus Jewish community and that homozygosity for this mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination. PMID: 20950787

Involvement in disease

Microcephaly, postnatal progressive, with seizures and brain atrophy (MCPHSBA)

Subcellular Location

Nucleus.

Protein Families

Mediator complex subunit 17 family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 2375

OMIM: 603810

KEGG: hsa:9440

STRING: 9606.ENSP00000251871

UniGene: Hs.444931

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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