MED23 Antibody

1. MED23 adopts an arch-shaped conformation, with an N-terminal domain (Nter) protruding from a large core region. PMID: 30140054
2. This is the first patient with documented refractory epilepsy caused by a novel homozygous pathogenic variant in MED23 expanding the phenotypic spectrum. Identification of the underlying genetic defect in MED23 sheds light on the possible mechanism of complete response to the ketogenic diet in this child. PMID: 27311965
3. a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8 PMID: 27579896
4. Higher l-arginine was associated with higher risk of Ischemic heart disease (odds ratio and of myocardial infarction, based on 2 SNPs from MED23. PMID: 27914500
5. MED23-associated intellectual disability has been found in two brothers from a non-consanguineous family. PMID: 25845469
6. MED23 plays an important role in hepatocarcinogenesis, and it may be a novel target for HCC therapy. PMID: 25684393
7. Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells. PMID: 25273169
8. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. PMID: 23340209
9. Data show that Med23 RNAi specifically inhibits the proliferation and tumorigenicity of lung cancer cells with hyperactive Ras activity. PMID: 22988093
10. missense mutation (p. R617Q) in MED23 that cosegregates with nonsyndromic autosomal recessive intellectual disability; mutation impaired response of JUN and FOS to mitogens by altering interaction between enhancer-bound transcription factors and Mediator PMID: 21868677
11. DRIP130 regulates HER2 expression by binding to ESX PMID: 12242338
12. loss of DRIP-130 expression, as a result of the gross loss of human chromosome 6q16.3-q23, provokes increased tumor metastasis PMID: 16964286
13. Sur2(CRSP3) is required for activation by Adenovirus E1A CR3 activation domain and is required for MAPK-mediated activation of Elk-1. PMID: 11934987

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HGNC: 2372

OMIM: 605042

KEGG: hsa:9439

STRING: 9606.ENSP00000357047

UniGene: Hs.29679