MEOX2 Antibody

1. MEOX2 polymorphism is associated with nonsyndromic cleft palate. PMID: 29030958
2. Findings suggest that miR-130a may be involved in the development of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by down-regulating GAX gene PMID: 28514291
3. MEOX2 may serve a protective role, enabling increased vessel formation despite exposure to a diabetes mellitus intrauterine environment. PMID: 27966787
4. 3D topography transiently induces concomitant upregulation of IL-1beta and MAPK ERK1/2 through nuclear factor-kappaB-dependent signaling pathway. PMID: 26041434
5. MEOX2 participates in chemoresistance irrespective of high CNV, but it is significantly dependent upon H3K27me3 enrichment probably associated with aggressiveness and chemotherapy failure in NSCLC patients PMID: 25460568
6. Genetic variation in MEOX2, but not TCF15, is a strong predictor of CHD. Further experimental studies should elucidate the underlying molecular mechanisms. PMID: 26428460
7. Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium. PMID: 25561514
8. downregulated expression of GAX is an independent prognostic factor and is correlated with poor survival in hepatocellular carcinoma patients PMID: 22644917
9. MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner. PMID: 22206000
10. Report of an interaction between a homeobox protein and IkappaBbeta in endothelial cells and suggest that MEOX2 modulates the activity of the RelA complex through direct interaction with its components. PMID: 20421348
11. homeobox protein Gax is expressed in vascular endothelium and strongly inhibits endothelial cell activation in response to growth factors and tube formation in vitro PMID: 12842453
12. The link of MEOX2 to neurovascular dysfunction in Alzheimer disease provides new mechanistic and therapeutic insights into this illness. PMID: 16116430
13. MEOX2 binding to RNF10 protein, human, was characterized. PMID: 16335786
14. GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences PMID: 17074759
15. miR-130a is a regulator of the angiogenic phenotype of vascular endothelial cells largely through its ability to modulate the expression of GAX and HOXA5 PMID: 17957028
16. MEOX2-induced senescence is dependent upon INK4a activity, and chromatin immunoprecipitation studies indicate that MEOX2 directly binds the INK4a promoter PMID: 19340300
17. ectopic Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1, and mediated induction of the cell cycle inhibitor gene p21. PMID: 19383287
18. Loss of MEOX2 gene is associated with Wilms tumor. PMID: 19760604

Show More

Hide All

HGNC: 7014

OMIM: 600535

KEGG: hsa:4223

STRING: 9606.ENSP00000262041

UniGene: Hs.170355