MNX1 Antibody

1. MNX1 may directly regulate TrkB expression, which may increase their metastatic potential via suppression of anoikis and enhanced adhesion to the ECM. PMID: 30066929
2. Pathogenic variants in MNX1 were detected in 28% of all CS cases and 25% of sporadic cases. The clinical phenotype was variable in patients with and without pathogenic variants; no significant genotype-phenotype correlation was observed. PMID: 29401559
3. Findings identify RGS12 as a candidate tumor-suppressor gene in AA prostate cancer, which acts by decreasing expression of AKT and MNX1, establishing a novel oncogenic axis in this disparate disease setting. PMID: 28611045
4. MNX1 as a novel targetable oncogene increased in African-American (AA) prostate cancer that is associated with aggressive disease. PMID: 27578002
5. Findings demonstrated for the first time that lncRNA MNX1-AS1 functions as an oncogene in ovarian cancer. PMID: 28414551
6. The results illustrated miR-200a and miR-141 could inhibit the expression of Hlxb9 by binding to its mRNA 3'UTR. Furthermore, the expression of miR-200a and miR-141 was almost reciprocal to that of Hlxb9. Overexpression of miR-200a and miR-141 downregulated the expression of pancreatic progenitor cell markers Hlxb9 PMID: 26801823
7. The nuclear positioning of the HLXB9 gene was monitored at different stages. PMID: 25136833
8. study reports the results of MNX1 mutational screening in a series of 28 cases suspected having Currarino Syndrome and characterization of 10 novel mutations PMID: 24095820
9. NKX2-2 and MNX1 are etiological genes for neonatal diabetes. PMID: 24411943
10. Both pHLXB9 and active GSK-3beta are elevated in beta cells with menin knockdown, in MEN1-associated beta cell tumors (insulinomas) PMID: 24425879
11. study describes a Norwegian family with typical Currarino syndrome in which a heterozygous deletion removes the entire MNX1 gene but no other known genes; also report MNX1 mutations in 3other Norwegian families and confirm that the GCC12 repeat (c.373_375[12]) is a normal allelic variant PMID: 23370340
12. HB9 binds to the prostaglandin E receptor 2 promoter and inhibits intracellular cAMP mobilization in leukemic cells. PMID: 23048027
13. a new HLXB9 gene mutation identified in a Chinese family with members suffering from Currarino syndrome PMID: 21960426
14. two novel mutations in the MNX1 gene in cases with Currarino syndrome PMID: 22820079
15. 2 previously described mutations, 1 de novo nonsense mutation (p.Gln212X) & 1 maternally inherited frameshift mutation (p.Pro18ProfsX38)were found among 14 Currarino syndrome patients with presacral tumors. PMID: 21763840
16. Hypermethylation of HLXB9 results in loss of expression and is associated with acute lymphoblastic leukemia. PMID: 21069786
17. HLXB9 is overexpressed in patients with infantile acute myeloid leukemia. PMID: 19446746
18. Incomeplete Curarino syndrome with more advantageous prognosis with autosomal domiant pattern homebox gene HLXBV9 mutation. PMID: 20146075
19. study reports on the MNX1 mutations in a family segregating Currarino syndrome (CS) & 3 sporadic CS patients & on clinical characteristics of the affected individuals PMID: 19853743
20. mutation in the HLXB9 transcription factor causes an autosomal dominant form of sacral agenesis PMID: 11940082
21. The chromosomal rearrangements of the HLXB9 protein locus at 7q36 were not detected in Hodgkin lymphoma cells unlike acute myeloid leukemia subsets expressing HLXB9. PMID: 15772702
22. High incidence of t(7;12)(q36;p13) in infant myeloid leukemia is associated with ectopic expression of HLXB9. PMID: 16646086
23. This study confirms that familial Currarino syndrome (CS) patients in Korea have the same genetic background as other ethnicities and reaffirms the phenotype variability among CS patients with the same mutation. PMID: 17612791
24. report 23 novel mutations in 26 patients among a series of 50 index cases with Currarino syndrome PMID: 18449898
25. MNX1-ETV6 fusion gene in an acute megakaryoblastic leukemia. PMID: 18940475
26. Ectopic expression of the HLXB9 gene is associated with an altered nuclear position in t(7;12) leukaemias PMID: 19212340

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HGNC: 4979

OMIM: 142994

KEGG: hsa:3110

STRING: 9606.ENSP00000252971

UniGene: Hs.37035