MRPL58 Antibody

Datasheet

Code	CSB-PA613490HA01HU
Size	US$166
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Image	Western blot All lanes: MRPL58 antibody at 2µg/ml Lane 1: A549 whole cell lysate Lane 2: Jurkat whole cell lysate Lane 3: K562 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 24 kDa Observed band size: 24 kDa Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA613490HA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA613490HA01HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MRPL58 Polyclonal antibody

Uniprot No.

Q14197

Target Names

MRPL58

Alternative Names

Digestion substraction 1 antibody; DS-1 antibody; DS1 antibody; Ict1 antibody; ICT1_HUMAN antibody; Immature colon carcinoma transcript 1 antibody; Immature colon carcinoma transcript 1 protein antibody; mitochondrial antibody; Peptidyl-tRNA hydrolase ICT1 antibody; Peptidyl-tRNA hydrolase ICT1, mitochondrial antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Peptidyl-tRNA hydrolase ICT1, mitochondrial protein (30-206AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MRPL58 Antibody (Product code: CSB-PA613490HA01HU) is Non-conjugated. For MRPL58 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA613490HB01HU	MRPL58 Antibody, HRP conjugated	ELISA
FITC	CSB-PA613490HC01HU	MRPL58 Antibody, FITC conjugated
Biotin	CSB-PA613490HD01HU	MRPL58 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

Gene References into Functions

High ICT1 expression is associated with leukemia. PMID: 29328466
ICT1 overexpression notably predicted poor prognosis of gastric cancer patients. PMID: 28987942
Study demonstrates that ICT1 overexpression correlates with malignant clinical features and poor prognosis of hepatocellular carcinoma (HCC) patients. Functionally, ICT1 promotes proliferation, cell cycle progression and inhibits apoptosis of HCC cells. ICT1 regulates the expressions of CDK1, cyclin B1, Bcl-2 and Bax, and is directly targeted by microRNA-134 (miR-134) in HCC cells. PMID: 29130100
ICT1 may play a crucial role in promoting gastric cancer proliferation in vitro. PMID: 29036264
The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity. PMID: 28826487
our preliminary study reveals the important role of ICT1 in NSCLC cells that knockdown of ICT1 significantly suppressed cell proliferation, arrested cell cycle though altering expression cell cycle regulators, and promoted cell apoptosis. PMID: 27413166
ICT1 knockdown significantly inhibited cell proliferation and migration, led to G2/M phase cell-cycle arrest, and triggered apoptosis via the intracellular AMPKa, SAPK/JNK, and PARP signaling pathways. PMID: 27411551
ICT1 was significantly upregulated in diffuse large B-cell lymphoma tissues (DLBCL) and correlated with poor survival. Knockdown of ICT1 remarkably induced cell cycle G0/G phase arrest and apoptosis in DLBCL cells. PMID: 28629825
ICT1 knockdown altered the expression of apoptosis- or cell cyclerelated proteins such as Bcl-2, caspase-3, CDK1, CDK2 and cyclin B. PMID: 28290601
ICT1 may be essential for hydrolysis of prematurely terminated peptidyl-tRNA moieties in stalled mitoribosomes. PMID: 20186120

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Subcellular Location

Mitochondrion.

Protein Families

Prokaryotic/mitochondrial release factor family, Mitochondrion-specific ribosomal protein mL62 subfamily

Tissue Specificity

Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.

Database Links

HGNC: 5359

OMIM: 603000

KEGG: hsa:3396

STRING: 9606.ENSP00000301585

UniGene: Hs.407955

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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