MT-CYB Antibody

Code CSB-PA581286
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA581286(MT-CYB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA581286(MT-CYB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
MT-CYB
Alternative Names
COB antibody; Complex III subunit 3 antibody; Complex III subunit III antibody; CYB_HUMAN antibody; CYTB antibody; Cytochrome b antibody; Cytochrome b c1 complex subunit 3 antibody; Cytochrome b-c1 complex subunit 3 antibody; Mitochondrially encoded cytochrome b antibody; MT-CYB antibody; MTCYB antibody; Ubiquinol cytochrome c reductase complex cytochrome b subunit antibody; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human MT-CYB
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Gene References into Functions
  1. The heteroplasmy level of some mutations in gene MT-CYB among women with asymptomatic atherosclerosis PMID: 29368910
  2. The effects of mutation in mitochondrially encoded cytochrome b are reviewed. PMID: 28132468
  3. Mitochondrial mutation m.15804T>C in the mtCYB gene in a family with fibromyalgia is associated with NLRP3-inflammasome activation. PMID: 26566881
  4. These results indicate that miR-151a-5p may participate in the regulation of cellular respiration and ATP production through targeting Cytb. PMID: 26626315
  5. The polymorphisms of CYTB as a very useful DNA marker were significantly different between different geographical Uyghur PMID: 24103151
  6. Significant elevation of ERalpha and MTCYB transcript levels in premenopausal leiomyomas and its association with ERalpha, -397 CC genotype suggests the mitochondrial-mediated role of estrogen as the promoter of leiomyoma tumorigenesis. PMID: 21506659
  7. mitocryptide-2 (MCT-2) and its human homolog hMCT-2 are cryptides that activate neutrophils PMID: 19342687
  8. The other proband had a non-synonymous G15221A mutation in the cytochrome b gene. PMID: 12031626
  9. In a mitochondrial myopathy patient, a novel stop-codon mutation (G15761A) was found in the mitochondrial DNA (mtDNA)-encoded cytochrome b gene, resulting in loss of the last 41 amino acids of the protein and complex III deficiency PMID: 12686403
  10. clinical/phenotypic variability of the G15498A mutation in mitochondrial DNA PMID: 14735157
  11. biochemical and molecular genetic studies of a patient with both muscle and brain involvement and a severe reduction in the activities of both complexes I and III in skeletal muscle due to a novel mutation in the MTCYB gene PMID: 16008558
  12. caspase 8-dependent cleavage of mitochondrial Cyt b and translocation of its C-terminal half into the cytoplasm occurred during FAS-induced apoptosis in both chicken and human cells PMID: 18796602
  13. CytbI7T has a role in longevity related to caloric restriction PMID: 19503808
  14. The m.15635T>C transition (S297P) was carried by a newborn who presented with a polyvisceral failure. PMID: 19563916
  15. cytochrome B gene mutation induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells. PMID: 19569044

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Involvement in disease
Cardiomyopathy, infantile histiocytoid (CMIH); Leber hereditary optic neuropathy (LHON)
Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
Cytochrome b family
Database Links

HGNC: 7427

OMIM: 500000

KEGG: hsa:4519

STRING: 9606.ENSP00000354554

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