Brain specific transmembrane protein antibody; Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 2 antibody; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2 antibody; BTCL2 antibody; FLJ10430 antibody; FLJ14724 antibody; FLJ90456 antibody; NEOT2 antibody; NETO 2 antibody; Neto2 antibody; NETO2_HUMAN antibody; Neuropilin (NRP) and tolloid (TLL) like 2 antibody; Neuropilin and tolloid like protein 2 antibody; Neuropilin and tolloid-like protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human NETO2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission.
Gene References into Functions
upregulation of NETO2 gene is first stipulated by the isoform 1 (NM_018092.4), and the probable mechanism of its activation is associated with the increased expression of SAP30 transcription factor. PMID: 29989576
NETO2 may be involved in colorectal cancer progression, but is not directly associated with epithelial-mesenchymal transition PMID: 29297384
Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors PMID: 26277340
NETO2 upregulation could serve as a potential biomarker for the prediction of advanced tumor progression and unfavorable prognosis in patients with colorectal carcinoma. PMID: 26699544
Determination of the neuropilin and tolloid-like protein 2 signal peptide cleavage site by N-terminal sequencing. PMID: 15340161
Rat neto2 plays a role in glutamate signaling in the brain by modulating the function of kainate receptors. PMID: 19217376