NETO2 Antibody

Datasheet

Code	CSB-PA015716GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8NC67

Target Names

NETO2

Alternative Names

Brain specific transmembrane protein antibody; Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 2 antibody; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2 antibody; BTCL2 antibody; FLJ10430 antibody; FLJ14724 antibody; FLJ90456 antibody; NEOT2 antibody; NETO 2 antibody; Neto2 antibody; NETO2_HUMAN antibody; Neuropilin (NRP) and tolloid (TLL) like 2 antibody; Neuropilin and tolloid like protein 2 antibody; Neuropilin and tolloid-like protein 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human NETO2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission.

Gene References into Functions

upregulation of NETO2 gene is first stipulated by the isoform 1 (NM_018092.4), and the probable mechanism of its activation is associated with the increased expression of SAP30 transcription factor. PMID: 29989576
NETO2 may be involved in colorectal cancer progression, but is not directly associated with epithelial-mesenchymal transition PMID: 29297384
Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors PMID: 26277340
NETO2 upregulation could serve as a potential biomarker for the prediction of advanced tumor progression and unfavorable prognosis in patients with colorectal carcinoma. PMID: 26699544
Determination of the neuropilin and tolloid-like protein 2 signal peptide cleavage site by N-terminal sequencing. PMID: 15340161
Rat neto2 plays a role in glutamate signaling in the brain by modulating the function of kainate receptors. PMID: 19217376

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Database Links

HGNC: 14644

OMIM: 607974

KEGG: hsa:81831

STRING: 9606.ENSP00000455169

UniGene: Hs.645802

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Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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