NEURL1 Antibody

Code CSB-PA070239
Size US$100
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Product Details

Uniprot No.
Target Names
NEURL1
Alternative Names
NEURL1 antibody; NEURL antibody; NEURL1A antibody; RNF67E3 ubiquitin-protein ligase NEURL1 antibody; EC 2.3.2.27 antibody; Neuralized-like protein 1A antibody; h-neu antibody; h-neuralized 1 antibody; RING finger protein 67 antibody; RING-type E3 ubiquitin transferase NEURL1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human Neuralized-1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Gene References into Functions
  1. NEURL rs12415501 and CAND2 rs4642101 are significantly associated with postoperative atrial fibrillation susceptibility after coronary artery bypass grafting among Chinese population PMID: 27203392
  2. Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1. PMID: 26276215
  3. This is a novel gene implicated in atrial fibrillation PMID: 25124494
  4. NEURL1 expression was downregulated in medulloblastoma compared to normal cerebellar tissue with lowest expression levels in hedgehog-activated tumors; conclude NEURL1 is candidate tumor suppressor in MB at least in part through effects on Notch pathway PMID: 20847082
Subcellular Location
Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse, postsynaptic density.
Tissue Specificity
Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.
Database Links

HGNC: 7761

OMIM: 603804

KEGG: hsa:9148

STRING: 9606.ENSP00000358795

UniGene: Hs.594708

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