NFYC Antibody

Code CSB-PA003427
Size US$100
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  • Western Blot analysis of 293 cells using NF-YC Polyclonal Antibody
  • Western Blot analysis of NIH-3T3 cells using NF-YC Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
NFYC
Alternative Names
CAAT box DNA binding protein subunit C antibody; CAAT box DNA-binding protein subunit C antibody; CBF C antibody; CBFC antibody; CCAAT binding factor subunit C antibody; CCAAT transcription binding factor subunit gamma antibody; DKFZp667G242 antibody; FLJ45775 antibody; H1TF2A antibody; HAP5 antibody; histone H1 transcription factor large subunit 2A antibody; HSM antibody; NF-YC antibody; NFYC antibody; NFYC_HUMAN antibody; Nuclear transcription factor Y gamma antibody; Nuclear transcription factor Y subunit C antibody; Nuclear transcription factor Y subunit gamma antibody; OTTHUMP00000009207 antibody; OTTHUMP00000009208 antibody; OTTHUMP00000009209 antibody; OTTHUMP00000009210 antibody; OTTHUMP00000009211 antibody; OTTHUMP00000009212 antibody; OTTHUMP00000009213 antibody; OTTHUMP00000009215 antibody; OTTHUMP00000009217 antibody; OTTHUMP00000231028 antibody; Transactivator HSM 1/2 antibody; transactivator HSM-1 antibody; Transactivator HSM-1/2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the N-terminal region of Human NF-YC.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Gene References into Functions
  1. NF-YC was significantly increased in gliomas. Knockdown of NF-YC reduced brain tumor size in vivo. NF-YC played as an independent predictor of patient survival. PMID: 27495011
  2. p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID: 28257042
  3. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair PMID: 25965574
  4. the expression of the adipogenic differentiation genes fatty acid binding protein-4, adiponectin, and leptin and the formation of fat droplets were impaired. PMID: 23657974
  5. NFY-C expression was elevated in colorectal adenocarcinomas; moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease PMID: 22104449
  6. Sp1, NF-Y and FOXO transcription factors are involved in the regulation of LKB1 transcription. PMID: 22412893
  7. NF-YC functions as a new corepressor of agonist-bound mineralocorticoid receptor via alteration of aldosterone-induced MR conformation PMID: 20054001
  8. role in repressing Smad2 and Smad3 transactivating activity PMID: 12023901
  9. C/EBPbeta contributes to the induction of hepatocyte replication in response to HGF in rodents, which is likely due to post-translational modifications. PMID: 15922473
  10. Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple neoplasms. PMID: 19559782
  11. NF-YC complexity is generated by dual promoters and alternative splicing PMID: 19690168

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Subcellular Location
Nucleus.
Protein Families
NFYC/HAP5 subunit family
Database Links

HGNC: 7806

OMIM: 605344

KEGG: hsa:4802

STRING: 9606.ENSP00000396620

UniGene: Hs.713051

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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