NID2 Antibody

1. High NID2 methylation is associated with non-small cell lung cancer. PMID: 29970687
2. the serum NID2 levels show significant elevation in the ESCC patients and those with relatively high serum NID2 levels ( 32.6 mu mu g/L) are significantly associated with poor survival outcome compared with those with very low serum NID2 levels (< < 20.0 mu mu g/L). PMID: 29278876
3. Addition of a TWIST1/NID2-based DNA methylation assay adds diagnostic value to urine cytology and the model is sensitive to the classification of equivocal cytology. PMID: 28106542
4. Promoter methylation of NID2 was significantly higher in nasopharyngeal carcinoma and esophageal squamous cell carcinoma cells. NID2 suppresses the EGFR/Akt and integrin/FAK/PLCgamma metastasis-related pathways. PMID: 27793011
5. Knockdown of nidogen-2 reduced SOX9 expression, whereas it up-regulated RUNX2 expression PMID: 26683663
6. The cleavage of nidogen-1 and -2 is partially inhibited in human tumor samples. PMID: 23681936
7. combined methylation analysis of Twist homolog 1 and nidogen-2 genes may be a simple, noninvasive, sensitive, and specific method for detecting cancer cells in urine. PMID: 23682613
8. Decreased nidogen-2 expression is associated with hepatocellular carcinoma PMID: 21815147
9. NID2 promoter hypermethylation is associated with oral cavity squamous cell carcinoma. PMID: 21558411
10. Nidogen-2 is a new biomarker for ovarian cancer which correlates closely with CA125. PMID: 19883638
11. short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2 PMID: 11733994
12. found to be ubiquitous component of basement membrane zones underneath developing epithelia of most of the major organ systems; may participate in cell biological functions during human development PMID: 12005023
13. Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene. PMID: 12475645
14. nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone PMID: 17008882
15. CpG islands of both NID1 and NID2 genes are aberrantly methylated in human cancer samples and cancer cell lines. PMID: 17328794

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HGNC: 13389

OMIM: 605399

KEGG: hsa:22795

STRING: 9606.ENSP00000216286

UniGene: Hs.369840