NIN Antibody

Datasheet

Code	CSB-PA843155LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA843155LA01HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NIN Polyclonal antibody

Uniprot No.

Q8N4C6

Target Names

NIN

Alternative Names

Centrosome Marker antibody; Glycogen synthase kinase 3 beta interacting protein antibody; GSK3B interacting protein antibody; h Glycogen synthase kinase 3 beta-interacting protein antibody; hNinein antibody; KIAA1565 antibody; NIN antibody; NIN protein antibody; NIN_HUMAN antibody; ninein (GSK3B interacting protein) antibody; Ninein antibody; Ninein centrosomal protein antibody; SCKL7 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ninein protein (80-185AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NIN Antibody (Product code: CSB-PA843155LA01HU) is Non-conjugated. For NIN Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA843155LB01HU	NIN Antibody, HRP conjugated	ELISA
FITC	CSB-PA843155LC01HU	NIN Antibody, FITC conjugated
Biotin	CSB-PA843155LD01HU	NIN Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Required for centriole organization and microtubule anchoring at the mother centriole.

Gene References into Functions

Our analyses suggest a relationship with prenatal neurogenesis and identify the human data point as an outlier, possibly explained by postnatal changes in development on the human lineage. PMID: 22937743
Ninein influences the rate of axonal growth and branching by affecting microtubule stability and dynamics. PMID: 25741725
JAK2 Tyrosine Kinase phosphorylates centrosomal protein ninein, which negatively regulates it PMID: 25332239
A Ninein (NIN) missense mutation identified in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. PMID: 23665482
The role of hNinein isoform 6 expression in cell differentiation was assessed in BrdU-treated IMR-32 cells PMID: 23047184
The prevalence of hNinein autoreactivity and its specificity in 22 rheumatoid arthritis and 32 systemic lupus erythematosus autoimmune disease sera. PMID: 21667027
Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. PMID: 21325031
Two single nucleotide polymorphisms in the APC and NIN loci were significantly associated with pancreatic cancer risk PMID: 20056645
Ninein is essential for the reformation of specific aspects of the interphase centrosome architecture following mitosis as well as being required for the centrosome to function as a MTOC. PMID: 11956314
ninein protein has two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle PMID: 12927815
Elevated ninein causes mislocalization of gamma-tubulin, recruiting it to ectopic (noncentrosomal) ninein-containing sites which are not active in nucleating microtubules, suggesting a regulatory role for ninein in microtubule nucleation. PMID: 15190203
We propose that ninein constitutes a molecular link between microtubule-nucleation and -anchoring activities at the centrosome. PMID: 15784680
our findings place SUMOylation target on the centrosome structure protein, hNinein, which results in the switch localization from centrosome to nucleus PMID: 16154161
analysis of human ninein isoforms that are regulated by centrosomal targeting signals and bind to gamma-tubulin PMID: 17102634
hNinein regulates the dynamic movement of Astrin throughout the cell cycle and this interaction, in turn, is required for maintenance of centrosome/spindle pole integrity. PMID: 17383637
Data show that ninein is highly dynamic and that, in epithelial cells, it is present not only at the centrosome but also in the cytoplasm as distinct speckles. PMID: 17698918

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Involvement in disease

Seckel syndrome 7 (SCKL7)

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.; [Isoform 6]: Cytoplasm.

Tissue Specificity

Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5.

Database Links

HGNC: 14906

OMIM: 608684

KEGG: hsa:51199

STRING: 9606.ENSP00000371472

UniGene: Hs.310429

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