NMNAT3 Antibody

Datasheet

Code	CSB-PA839418LA01HU
Size	US$166
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Image	Western blot All lanes: NMNAT3 antibody at 2µg/ml + Mouse brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 29, 25, 19 kDa Observed band size: 29 kDa Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA839418LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA839418LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NMNAT3 Polyclonal antibody

Uniprot No.

Q96T66

Target Names

NMNAT3

Alternative Names

NaMN adenylyltransferase 3 antibody; Nicotinamide mononucleotide adenylyltransferase 3 antibody; Nicotinamide nucleotide adenylyltransferase 3 antibody; Nicotinate-nucleotide adenylyltransferase 3 antibody; NMN adenylyltransferase 3 antibody; NMNA3_HUMAN antibody; NMNAT 3 antibody; Nmnat3 antibody; PNAT 3 antibody; PNAT-3 antibody; PNAT3 antibody; Pyridine nucleotide adenylyltransferase 3 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 protein (1-215AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NMNAT3 Antibody (Product code: CSB-PA839418LA01HU) is Non-conjugated. For NMNAT3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA839418LB01HU	NMNAT3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA839418LC01HU	NMNAT3 Antibody, FITC conjugated
Biotin	CSB-PA839418LD01HU	NMNAT3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.

Gene References into Functions

NMNAT3 is absent in mitochondria in human cells, and, akin to plants and yeast, cytosolic NAD maintains the mitochondrial NAD pool. PMID: 24155910
Red blood cells represent the first human cell type with a remarkable predominance of NMNAT3 over NMNAT1; NMNAT2 is absent. PMID: 20457531
analysis of isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases PMID: 20388704
NMNAT1 is a nuclear protein, whereas NMNAT2 and -3 are localized to the Golgi complex and the mitochondria PMID: 16118205
NMN binds before ATP with the mitochondrial isozyme NMNAT3. Only NMNAT3 utilizes ITP efficiently in place of ATP, and NMNH conversion to NADH by NMNAT1 and NMNAT3 occurs at similar rates. PMID: 17402747

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Subcellular Location

Mitochondrion.

Protein Families

Eukaryotic NMN adenylyltransferase family

Tissue Specificity

Expressed in lung and spleen with lower levels in placenta and kidney.

Database Links

HGNC: 20989

OMIM: 608702

KEGG: hsa:349565

STRING: 9606.ENSP00000340523

UniGene: Hs.208673

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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