NPM3 Antibody

Datasheet

Code	CSB-PA049852
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA049852(NPM3 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA049852(NPM3 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, Jurkat cells, Primary antibody: CSB-PA049852(NPM3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O75607

Target Names

NPM3

Alternative Names

NPM 3 antibody; NPM3 antibody; NPM3_HUMAN antibody; Nub1 antibody; nucleophosmin/nucleoplasmin family, member 3 antibody; nucleophosmin/nucleoplasmin, 3 antibody; Nucleoplasmin 3 antibody; Nucleoplasmin-3 antibody; PORMIN antibody; RGD1565542 antibody; TMEM123 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human NPM3

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:100-1:300

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM.

Gene References into Functions

Studies indicate that histone chalerones nucleoplasmin (NPM2/NPM3) preferentially associated with histones H2A-H2B in the egg and the nuclear autoantigenic sperm protein (NASP) families. PMID: 22968912
Characterization of the sperm chromatin decondensation and nucleosome assembly activities of homo- and hetero-oligomers of NPM1,NPM2 and NPM3. PMID: 22362753
NPM3 lacks intrinsic histone chaperone activity, inhibits histone assembly activity of NPM1 in vitro, and dramatically enhances transcription in a cellular system. PMID: 20073534
Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with putative histone chaperone NPM3. PMID: 19710011

Subcellular Location

Nucleus. Nucleus, nucleolus.

Protein Families

Nucleoplasmin family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 7931

OMIM: 606456

KEGG: hsa:10360

STRING: 9606.ENSP00000359128

UniGene: Hs.90691

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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