NPPC Antibody

1. two heterozygous NPPC mutations, located in the highly conserved ring, were identified; mutations cause autosomal dominant short stature in humans PMID: 28661490
2. This study showed that Plasma concentrations of amino-terminal proCNP are depressed in Parkinson's Disease. PMID: 28673612
3. C-type natriuretic peptide (CNP)administration significantly decreased the secretion and expression of MMP-2 and MMP-9 in the cultured mesangial cells ; (2) the secretion and expression of TIMP-1 progressively elevated after treatment with CNP for 24 and 48 h, whereas declined at later time point; (3) CNP expression was negatively correlated with MMP-2 and MMP-9 expression. PMID: 28554303
4. CNP level in pericardial fluid is a more sensitive marker of LV dysfunction than CNP levels in plasma in coronary artery disease patients undergoing coronary artery bypass grafting. PMID: 26962968
5. Data suggest mutations in NPR2 in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2; A488P mutation sets phosphorylation as requirement for CNP-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 = atrial natriuretic factor receptor B; CNP = C-type natriuretic peptide) PMID: 28450398
6. CNP may play a more important role than BNP and ANP related peptides, as risk marker of obesity PMID: 27376982
7. CNP and FGF-23 act through a close or reciprocal pathway and are in agreement with recent studies demonstrating a down-regulatory role of the mitogen-activated protein kinase activity by CNP PMID: 26459742
8. CNP/NPR-B can affect sperm motility and acrosome reaction, thus regulating the reproductive function of males PMID: 25926602
9. CNP levels rose after paroxysmal supraventricular tachycardia and continued to rise after the termination. PMID: 26801306
10. examined whether CNP reduces hyaluronan production and export via members of the multidrug resistance protein (MRP) and diminishes pro-inflammatory effects in chondrocytes PMID: 26307537
11. Plasma CNP might serve as a useful predictor for the therapeutic efficacy of metoprolol on postural tachycardia syndrome in children. PMID: 25811760
12. CNP/proCNP could be new markers in human prostate cancer PMID: 25808436
13. This case supports the concept that NPPC is overexpressed because of the loss of a specific negative regulatory control in the normal chromosomal location, and demonstrates the effectiveness of targeted resequencing in the mapping of breakpoints. PMID: 25728306
14. An increased level of NT-pro CNP is a promising non-invasive marker of hepatitis C related CLD complications and disease progression. PMID: 26485840
15. CNP effectively attenuated LPS-induced endothelial activation by inhibiting the NF-kappaB and p38 signaling pathways. PMID: 25096521
16. In achondroplasia, hypochondroplasia, and thanatophoric dysplasia, elevated plasma levels of proCNP products suggest the presence of tissue resistance to CNP. PMID: 25387261
17. Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium. PMID: 24099862
18. This is the first report of a circulating preproCNP derived signal peptide. PMID: 24845564
19. Gene expression of C-type natriuretic peptide and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects PMID: 22884919
20. C-type natriuretic peptide expression increases in human leukocytes of patients with chronic heart failure as a function of clinical disease severity. PMID: 23911666
21. Acute inflammation in young children potently reduces CNP production. PMID: 23732776
22. these observations suggest that CNP and its specific receptor, NPR-B, can play a very important role in regulating cardiac hypertrophy and remodeling, indicating NPR-B as a new potential drug target for the treatment of cardiovascular disease. PMID: 23262354
23. DNA sequence analysis, single nucleotide polymorphism characterization and miRNA binding site identification in the 3'UTR of the human NPPC gene. PMID: 23542429
24. CNP synthesis (as measured by NTproCNP levels in plasma) is closely related to linear growth in healthy children at all ages. We propose NTproCNP as a biomarker of linear growth. PMID: 22435455
25. CNP production and clearance are increased in boys with Klinefelter syndrome. PMID: 22962429
26. NPR2 expression in normal human fetal and adult pituitaries and adenomatous pituitary tissue and suggest a role for these receptors in both pituitary development and oncogenesis. PMID: 22645228
27. Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery. PMID: 22421372
28. Serum NT-proCNP is elevated in advanced liver diseases and has prognostic value in cirrhotic patients. PMID: 22285383
29. Continuous intravenous infusion of C-type natriuretic peptide did not attenuate the development of pulmonary hypertension caused by hypoxia and VEGF receptor blockade. PMID: 21820448
30. The concentrations of amino-terminal pro-C-type natriuretic peptide in rheumatoid arthritis patients were significantly increased when compared to healthy controls. PMID: 20934962
31. 56-year-old woman with Budd-Chiari syndrome who underwent liver transplantaation in whom heart failure was successfully managed using serial monitoring of BNP concentrations. PMID: 20832589
32. The study indicates functional signaling by B- and C-type natriuretic peptides in vascular endothelial cells, supporting possible roles of these mediators in regulating endothelial cell function. PMID: 20085572
33. Results support role of TSC22D1 as an enhancer of CNP transcription and suggest that TGF-beta-induced upregulation of CNP expression in smooth muscle may be mediated in part by increased transcription of TSC22D1. PMID: 20802130
34. NT-proCNP was associated with the endosteal apposition of bone at the distal forearm in females with a persistent eating disorder PMID: 20551602
35. Data suggest that decreased plasma proCNP concentration in idiopathic intracranial hypertension may reflect endothelial dysregulation of vascular tone and may be a marker in this disease. PMID: 20553977
36. CNP/NPR-B signaling pathway is activated during TGF-beta1 induced chondrogenic differentiation of human trabecular bone-derived mesenchymal stem cells. PMID: 20721606
37. new proCNP assay shows that proCNP is abundantly present in human seminal plasma and that seminal proCNP is secreted from the prostate gland and/or the seminal vesicles. PMID: 20797397
38. Our data demonstrates that generation of CNP is not enhanced under heart failure condition like Chagas disease; CNP rise by severe HF is caused by its less degradation that is independent of neutral endopeptidase activity PMID: 20090473
39. findings demonstrate that CNP metabolism is altered in patients with nephrotic syndrome and support the hypothesis that activation of renal CNP can be partially offset by a low-protein diet PMID: 12167597
40. CNP G2628A polymorphism made an even greater contribution to hypertension in the younger subpopulation. PMID: 12452325
41. human pro-CNP processing requires furin PMID: 12736257
42. Particulate guanylate cyclase activation by CNP induces a post-transductional down-regulation of soluble guanylate cyclase by a mechanism involving PKG and the proteasome pathway PMID: 14654233
43. The first intron in the CNP sequence does not contain any additional enhancer-binding sites. However, the signal sequence is indispensable for secretion of CNP and its appropriate physiological function. PMID: 15231517
44. BNP levels appear to be elevated in coronary disease, especially in acute coronary syndromes, even in the absence of systolic dysfunction PMID: 15598085
45. discussion of C-type natriuretic peptide and guanylyl cyclase B receptor [review] PMID: 15911070
46. NT-proCNP may have a role in growth velocity and bone formation PMID: 16006435
47. CNP is capable of autoregulating the expression of its cognate receptor. PMID: 16109786
48. CNP is a modulator of acute inflammation in the blood vessel wall characterized by leukocyte and platelet activation, mediated, at least in part, via suppression of P-selectin expression. PMID: 16179391
49. report suggests that in humans, platelet-derived growth factor(PDGF) and downstream activation of protein kinase C could represent an important control for natriuretic peptide precursor C expression in vascular smooth muscle PMID: 16777970
50. There is a discordant expression of NPPC in newborn infants of mothers with type 1 diabetes. PMID: 17289171

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HGNC: 7941

OMIM: 600296

KEGG: hsa:4880

STRING: 9606.ENSP00000295440

UniGene: Hs.247916