NUB1 Antibody

1. Mdm2 acts as a positive regulator of NUB1 function, by modulating NUB1 ubiquitination on lysine 159. PMID: 28099510
2. data suggest that NUB1 participates in telomere maintenance by regulating the levels of TRF1 at telomeres through both NEDD8-dependent and NEDD8-independent pathways. PMID: 27214791
3. NUB1L suppresses atypical neddylation and promotes the degradation of misfolded proteins by the proteasome PMID: 26260793
4. Based on biochemical features of the VBM motifs, we also identified NUB1L (NEDD8 ultimate buster-1 long) as a novel VBM-containing protein, which is involved in proteasomal degradation of NEDD8 through the P97 pathway. PMID: 24100225
5. In coordination with the P97-UFD1-NPL4 complex (P97(UFD1/NPL4)), NUB1L promotes transfer of NEDD8 to proteasome for degradation. PMID: 24019527
6. This study identified genes modifying endogenous mHTT using high-throughput screening and demonstrate NUB1 as an exemplar entry point for therapeutic intervention of Huntington's disease. PMID: 23525043
7. Data propose that NUB1, by regulating GSK3beta levels, modulates tau phosphorylation and aggregation, and is a key player in neurodegeneration associated with tau pathology. PMID: 22965877
8. In the present study, the proportions of intranuclear inclusion positive for NEDD8, NUB1 and SUMO-1 were significantly lower in glial cells than in neurons. PMID: 22612509
9. The finding of this study suggested that NUB1 along with abnormal alpha-synuclein is involved in the pathogenesis of Lewy body disease. PMID: 21937912
10. NUB1 has a splicing variant, NUB1L, which regulates the NEDD8 conjugation system PMID: 12816948
11. These results imply that the ubiquitin precursor UbC1 hydrolysis mediated by NEDD8 ultimate buster-1 (NUB1) is involved in cellular functions in the seminiferous tubules such as spermatogenesis. PMID: 15009209
12. NUB1L not only acts as a linker between the 26 S proteasome and ubiquitin-like proteins, but also as a facilitator of proteasomal degradation. PMID: 16707496
13. These results suggest that NUB1 indeed targets synphilin-1 to the proteasome for its efficient degradation, which, because of the resultant reduction in synphilin-1, suppresses the formation of synphilin-1-positive inclusions. PMID: 16877356

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HGNC: 17623

OMIM: 607981

KEGG: hsa:51667

STRING: 9606.ENSP00000457628

UniGene: Hs.647082