NUP85 Antibody

Code CSB-PA874821LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: HEK293 whole cell lysate, NIH/3T3 whole cell lysate, Mouse kidney tissue
    All lanes: NUP85 antibody at 2.7μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 76, 53, 70 kDa
    Observed band size: 76, 70 kDa
  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA874821LA01HU at dilution of 1:100
  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA874821LA01HU at dilution of 1:100
  • Immunofluorescent analysis of MCF-7 cells using CSB-PA874821LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NUP85 Polyclonal antibody
Uniprot No.
Target Names
NUP85
Alternative Names
85 kDa nucleoporin antibody; FLJ12549 antibody; FROUNT antibody; Frount protein antibody; Nuclear pore complex protein nucleoporin 85 kDa antibody; nuclear pore complex protein nucleoporin Nup75 antibody; Nuclear pore complex protein Nup85 antibody; Nucleoporin 85 antibody; Nucleoporin 85kDa antibody; Nucleoporin nucleoporin 85kDa antibody; Nucleoporin Nup75 antibody; Nucleoporin NUP85 antibody; nucleoporin, 75-KD antibody; Nucleoporin85 antibody; Nup 75 antibody; NUP 85 antibody; Nup75 antibody; nup85 antibody; NUP85_HUMAN antibody; PCN antibody; PCNT 1 antibody; PCNT antibody; PCNT, formerly antibody; PCNT1 antibody; Pericentrin antibody; Pericentrin, formerly antibody; Pericentrin-1 antibody; Pericentrin1 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Nuclear pore complex protein Nup85 protein (201-500AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NUP85 Antibody (Product code: CSB-PA874821LA01HU) is Non-conjugated. For NUP85 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA874821LB01HU NUP85 Antibody, HRP conjugated ELISA
FITC CSB-PA874821LC01HU NUP85 Antibody, FITC conjugated
Biotin CSB-PA874821LD01HU NUP85 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:2000-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Involved in nephrogenesis.
Gene References into Functions
  1. results support a model of CCR2 equilibrium: chemokine binding changes the conformational equilibrium of CCR2 toward the active state, and Pro-C switches its binding partner from the membrane to FROUNT PMID: 25283965
  2. Residues on the hydrophobic side are completely conserved among FROUNT-binding receptors. PMID: 24128342
  3. Data show that the C Terminus of Nup120 Directly Binds Nup145C and Nup85. PMID: 19576787
  4. The CCL2/CCR2 pathway via FROUNT may influence the clinical severity of CHF. PMID: 17395051
  5. FROUNT binds to the C-terminal domain of CCR5 in addition to that of CCR2. PMID: 19841162

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Subcellular Location
Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane.
Protein Families
Nucleoporin Nup85 family
Database Links

HGNC: 8734

OMIM: 170285

KEGG: hsa:79902

STRING: 9606.ENSP00000245544

UniGene: Hs.362817

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