OAT Antibody

Datasheet

Code	CSB-PA020180
Size	US$100
	Order now
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P04181

Target Names

OAT

Alternative Names

OAT antibody; Ornithine aminotransferase antibody; mitochondrial antibody; EC 2.6.1.13 antibody; Ornithine delta-aminotransferase antibody; Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase antibody; hepatic form; Ornithine aminotransferase antibody; renal form] antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human OAT.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.

Gene References into Functions

OAT Val332-to-Met substitution identified in pyridoxine-responsive gyrate atrophy patients does not significantly affect the spectroscopic and kinetic properties of OAT, but during catalysis it makes the protein prone to convert into the apo-form, which undergoes unfolding and aggregation under physiological conditions. PMID: 30251682
identified Arg217 as an important hot-spot at the dimer-dimer interface of hOAT and demonstrated that the artificial dimeric variant R217A exhibits spectroscopic properties, Tm values and catalytic features similar to those of the tetrameric species. This finding indicates that the catalytic unit of hOAT is the dimer. PMID: 28345116
Sequencing of the gene for ornithine aminotransferase reveals a homozygous mutation in our patient (base exchange c.498C>A in Exon 4). PMID: 26259030
Neurogenesis is inhibited by X-OAT during Xenopus embryonic development, but it is essential for Xenopus embryonic development. The Arg 180 and Leu 402 are crucial for these effects of the OAT molecule in development. PMID: 25783604
Our report describes the first case of gyrate atrophy in the Korean population diagnosed by OAT gene analysis and treated with vitamin B6 dietary supplementation. PMID: 24082780
We identified a novel frameshift mutation (p.K169DfsX10) in the OAT gene. While an early arginine-restricted dietary treatment suppressed the fundus changes PMID: 24429551
Data suggest that other factors besides the specific ornithine aminotransferase (OAT) genotype modulate atrophy of choroid and retina (GA) phenotype in patients. PMID: 23076989
OAT was a highly homologous and stable protein located in the mitochondria. PMID: 22989455
Molecular analysis revealed a new deletion c.532_536delTGGGG (p.Trp178X) and a known mutation c.897C>G (p.Tyr299X) in the OAT gene. PMID: 22674428
Fundus autofluorescence imaging can reveal the extent of neurosensory dysfunction in gyrate atrophy patients. PMID: 22182799
analysis of ornithine aminotransferase substrate specificity PMID: 16096275

Hide All

Involvement in disease

Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA)

Subcellular Location

Mitochondrion matrix.

Protein Families

Class-III pyridoxal-phosphate-dependent aminotransferase family

Database Links

HGNC: 8091

OMIM: 258870

KEGG: hsa:4942

STRING: 9606.ENSP00000357838

UniGene: Hs.523332

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Neutralizing Antibody Stands Out Among Antiviral Therapies Lysosomal Enzymes and Lysosomal Storage Disorders (LSDs) NKG2D, a Powerful Molecule Involved In CAR-T And Car-NK Cell Therapy How to Choose? Polyclonal, Monoclonal, or Recombinant Antibody? DT3C, a Powerful Tool for ADC Drug Internalization In Vitro The Collection of Progress of Anti-GPCR Antibody Drugs A Review of WFDC8 Antibody Tag Antibodies, Your Good Partner in Protein Research The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application How to Choose the Right Secondary Antibody? Anti-Payload Antibody DXD: A Highly Potent Tool for ADCs Pharmacokinetic (PK) Analysis! One World, One Hope——What Can We Do about AIDS? The difference between primary antibody and secondary antibody Do you Often Trouble in These Problems of ELISA? What Factors Could Affect ELISA Results? CD20 Monoclonal Antibodies Drugs: There is an Explosion of New mAbs Against CD20! The Overview of Coagulation Understanding of Serum Albumin VSIG4: a Prominent B7 Family Costimulatory Molecule or Complement Receptor in Cancers and Inflammatory Diseases! The Overview of Hippo Signaling Pathway About Thyroid Tumor, This Information You Must Know! GPCR Drugs Discovery CD Antigens - From Leucocytes Surface Markers to Diagnostic Markers for Cancer What Is an Antibody? Exploring the Science of Influenza A Virus: What You Need to Know How to choose a suitable expression vector? The Overview of Chemokine IL-17A: A Major Cytokine of the IL-17 Family, a Key Inflammation Target in Skin Diseases, or Inflammation-Associated Cancers! Do You Really Know Neurons and Glia Cells in Nerve System? Apoptosis mediated by death receptor Tumor Necrosis Factor (TNF) Tumor markers A Group of Promising Proteins - Cell Cycle Markers The Overview of Organelles Four Types of ELISA How to Choose an Antibody for Scientific Research? The Overview of Phage Display：Protocol, Classification, Application and FAQs The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of Wnt signaling pathway The overview of TGF-β signaling pathway The Encyclopedia of Common Virus PI3K-Akt Signaling Pathway and Cancer What Is Tomato Mosaic Virus What Should You Know about Exosomes? CADM1: an Immunoglobulin Superfamily Molecule, a New Tumor Suppressor Gene! Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Place an order now

I. Product details

Product name *

Code *

Size *

Quantity *

Message

II. Contact details

Name *

Email address *

Company/Organization

Phone

III. Ship To

Address *

City *

State/Province *

Zip/Post code *

Country *

Attn Name *

Phone# *

IV. Bill To Same as Shipping Address