ORAOV1 Antibody

1. provides the first evidence of ORAOV1 overexpression in esophageal squamous cell cancer and esophageal squamous intraepithelial neoplasia PMID: 25732110
2. the ORAOV1 gene is frequently amplified in esophageal squamous cell cancer PMID: 24930674
3. The ORAOV1 complex could prevent ROS-induced ribosomal damage, explaining why overexpression of ORAOV1 is so common in solid tumours PMID: 23318452
4. overexpression of ORAOV1 in non-tumoral margin samples can occur in absence of amplification. weak correlation between ORAOV1 amplification and expression in OSSC suggests ORAOV1 expression can be regulated by mechanisms other than gene amplification. PMID: 21623924
5. An oral cancer overexpressed 1 (ORAOV1) gene was identified as a probable target within the 11q13 amplicon in lymph node metastases from gastric adenocarcinoma. PMID: 21993861
6. ORAOV1 has an important role in regulating cell growth of cervical cancer HeLa cells through regulating the cell cycle and apoptosis. PMID: 20105337
7. High-resolution mapping of the 11q13 amplicon and identification of a gene that is amplified and overexpressed in oral cancer cells PMID: 12172009
8. data suggested potential roles in oral carcinogenesis and that TAOS1 might be involved earlier than EMS1. Both genes might be candidate biomarkers for diagnosis and prognosis in OSCC PMID: 17005439
9. ORAOV1 plays pivotal roles in the growth and angiogenesis of oral squamous cell carcinoma. PMID: 18688849
10. In OSCC tissue samples, the expression frequency of ORAOV1-A (51.1%) was much higher than that in normal samples (10.5%). ORAOV1-A may play a functional role in the tumorigenesis of OSCC. PMID: 19493886

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HGNC: 17589

OMIM: 607224

KEGG: hsa:220064

STRING: 9606.ENSP00000279147

UniGene: Hs.667996