OSBPL10 Antibody

Code CSB-PA017245GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
OSBPL10
Alternative Names
FLJ20363 antibody; ORP-10 antibody; ORP10 antibody; OSB10_HUMAN antibody; OSBP related protein 10 antibody; OSBP-related protein 10 antibody; OSBP9 antibody; OSBPL 10 antibody; OSBPL10 antibody; Oxysterol binding protein like 10 antibody; Oxysterol binding protein related protein 10 antibody; Oxysterol-binding protein-related protein 10 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human OSBPL10
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine.
Gene References into Functions
  1. Data indicate that the apoB-100 secretion phenotype is replicated in HepG2 cells transduced with the ORP10 shRNA lentiviruses. PMID: 22906437
  2. Single-nucleotide polymorphisms in OSBPL10 is associated with peripheral arterial disease. PMID: 20610895
  3. Overall, the rs2290532 (D254N) polymorphism in OSBPL10 may predispose individuals to hyper-LDL cholesterolemia. PMID: 20224571
  4. Analysis of variants in three genes encoding OSBP homologues in families with familial low high-density lipoprotein levels or familial combined hyperlipidemia revealed linkage of OSBPL10 single-nucleotide polymorphisms with high triglyceride trait. PMID: 19554302
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
OSBP family
Database Links

HGNC: 16395

OMIM: 606738

KEGG: hsa:114884

STRING: 9606.ENSP00000379804

UniGene: Hs.150122

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