OSBPL3 Antibody

Code CSB-PA017249GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
OSBPL3
Alternative Names
DKFZp667P1518 antibody; KIAA0704 antibody; MGC21526 antibody; ORP 3 antibody; ORP-3 antibody; ORP3 antibody; OSBL3_HUMAN antibody; OSBP related protein 3 antibody; OSBP-related protein 3 antibody; OSBP3 antibody; Osbpl3 antibody; Oxysterol binding protein 3 antibody; Oxysterol binding protein like 3 antibody; Oxysterol binding protein related protein 3 antibody; Oxysterol-binding protein-related protein 3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human OSBPL3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.
Gene References into Functions
  1. It indicates that VAPB along with ORP3 plays a central role in maintenance of the intracellular PtdIns4P gradient. PMID: 26812496
  2. phosphorylation of ORP3 controls its association with VAPA. Furthermore, ORP3-VAPA complexes stimulate R-Ras signaling. PMID: 25447204
  3. The intracellular targeting determinants of oxysterol binding protein (OSBP)-related protein 3 (ORP3) were studied using a series of truncated and point mutated constructs. PMID: 16143324
  4. The present findings demonstrate a new function of ORP3 as part of the machinery that controls the actin cytoskeleton, cell polarity and cell adhesion. PMID: 18270267
Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell projection, filopodium tip. Nucleus membrane; Peripheral membrane protein.
Protein Families
OSBP family
Tissue Specificity
Expressed in a subset of small lymphocytes (at protein level). Expressed at high concentration in kidney, lymph node and thymus. Expressed at moderate concentration in stomach, jejunum, ileum, appendix, spleen, leukocytes, trachea, lung and thyroid gland.
Database Links

HGNC: 16370

OMIM: 606732

KEGG: hsa:26031

STRING: 9606.ENSP00000315410

UniGene: Hs.520259

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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