OTX1 Antibody

1. High OTX1 expression is associated with gastric cancer. PMID: 30066897
2. We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects. PMID: 28599093
3. OTX1 and OTX2 genes might have a role in the pathogenesis of different types of sinonasal neoplasms. PMID: 28348423
4. Genitalia defects in these patients could result from the effect of OTX1. PMID: 25203062
5. overexpression of OTX1 results in accumulation of colorectal cancer (CRC) cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression inhibits the proliferative and invasive capability of CRC cell lines PMID: 24388989
6. XPO1 and OXT1 may contribute to ASD in 2p15-p16.1 deletion cases and non-deletion cases of ASD mapping to this chromosome region. PMID: 21750575
7. established that the p53 protein directly induces OTX1 expression by acting on its promoter PMID: 21478910
8. The early expression of OTX1 in proliferative cell layers of the human fetal brain supports the concept that this homeobox gene is important in neuronal cell development and differentiation. PMID: 20354145
9. This study identifies OTX1 as a molecular marker for high-grade germinal center derived Non-Hodgkin Lymphoma PMID: 19893048
10. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus candidate gene PMID: 11901358
11. OTR1, OTX2 and CRX act as positive modulators of the BEST1 promoter in the retinal pigment epithelium. PMID: 18849347
12. In the human fetal eye, OTX1 expression was confined to anterior retina. PMID: 19414065

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HGNC: 8521

OMIM: 600036

KEGG: hsa:5013

STRING: 9606.ENSP00000282549

UniGene: Hs.734360