PARVB Antibody

1. PARVB protein PMID: 25776890
2. Protein expression of beta-Parvin increases with colorectal cancer progression. PMID: 26115385
3. Taken together, our results indicate that 24-MCF treatment increases parvin-beta expression, which may inhibit ILK downstream signaling. PMID: 26549231
4. study found polymorphisms of rs5764455 and rs6006473 in PARVB gene in the Han Chinese population, and these polymorphisms were associated with the occurrence and progression of NAFLD. PMID: 26343796
5. Our results suggested that variations, including insertion/deletions, in PARVB, as well as those in PNPLA3, are important in the progression of NAFLD. PMID: 24621583
6. PARVB overexpression is a candidate biomarker for endophytic tumours and metastasis. PMID: 25422907
7. PARVB plays a potential role in the pathogenesis of coronary restenosis. PMID: 23950981
8. alpha-parvin, beta-parvin and migfilin were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively. PMID: 23099104
9. proper localization of beta-parvin to focal adhesions requires both the paxillin and integrin-linked kinase binding sites and that paxillin is important for early targeting of beta-parvin. PMID: 22869380
10. Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication. PMID: 20345489
11. downexpression of ParvB level in urothelial cell carcinoma of the upper urinary tract (UUT-UC) correlated with tumour stage, and was an independent unfavourable prognostic factor for disease-specific survival of patients with UUT-UC PMID: 20736946
12. Data from functional molecular imaging demonstrated that beta-parvin plays a regulatory role in the ILK-mediated Akt (also called protein kinase B) signaling cascades, suggesting that beta-parvin might be a crucial modulator of cell survival. PMID: 20164304
13. Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization. PMID: 11722847
14. the ILK-affixin complex has a role in integrin-cytoskeleton linkage during platelet aggregation [affixin] PMID: 12372433
15. affixin provide a novel signalling pathway that links integrin signalling to Cdc42/Rac1 activation. PMID: 15005707
16. ILK-affixin complex serves as an integrin-anchoring site for alpha-actinin and thereby mediates integrin signaling to alpha-actinin, which has been shown to play a critical role in actin polymerization at focal adhesions. PMID: 15159419
17. alpha- and beta-parvins play distinct roles in Rac activation or lamellipodium formation and protection of cells from apoptosis. PMID: 15284246
18. loss of ParvB expression is a novel mechanism for upregulating ILK activity in tumors PMID: 15467740
19. Data show that affixin is a dysferlin binding protein that colocalizes with dysferlin at the sarcolemma of normal skeletal muscle. PMID: 15835269
20. Parvin-beta might influence breast cancer progression PMID: 17998334
21. results suggest that affixin is involved in reorganization of subsarcolemmal cytoskeletal actin by activation of Rac1 through alpha and betaPIXs in skeletal muscle PMID: 18325335

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HGNC: 14653

OMIM: 608121

KEGG: hsa:29780

STRING: 9606.ENSP00000384515

UniGene: Hs.475074