PDE4B Antibody

1. Data suggest that maternal glycemic response during pregnancy is associated with lower DNA methylation of 4 CpG sites within PDE4B gene in placenta (collected after term birth); 3 additional CpG sites are differentially methylated relative to maternal glucose response within TNFRSF1B, LDLR, and BLM genes. (TNFRSF1B = TNF receptor superfamily member-1B; LDLR = low density lipoprotein receptor; BLM = Bloom syndrome protein) PMID: 29752424
2. Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition. PMID: 29100790
3. HTT forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4) to regulate PDE4 activity. PMID: 28263187
4. Low PDE4B expression is associated with sepsis. PMID: 28356347
5. PDE4B gene may be involved in the testicular abnormalities of men with DS and cryptorchidism. PMID: 25546171
6. This meta-analysis suggests that PDE4B SNPs are genetically associated with susceptibility to schizophrenia. PMID: 26756575
7. Our results suggest that PDE4B does not play an important role during the chemotactic response of human neutrophils PMID: 26011935
8. Our results support previously reported association of PDE4B variations with schizophrenia in other populations. PMID: 25926551
9. analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 PMID: 25831493
10. ototopical post-inoculation administration of a PDE4 inhibitor suppresses inflammation in this animal model, thus demonstrating the therapeutic potential of targeting PDE4 PMID: 23575688
11. PDE4B was found to be highly expressed in CD4+ lymphoid cancer cells, which suggests that it may represent a physiological role unique to the CD8+ and lymphoid cancer cells and thus might represent a target for treatment of certain lymphoid diseases PMID: 23451206
12. Short Disrupted-in-Schizophrenia (DISC)1 splice variants show reduced or no binding to nudE nuclear distribution E homolog (NDEL)1 and PDE4B proteins but fully interact with fasciculation/elongation zeta (FEZ)1 and glycogen synthase kinase 3 GSK3beta. PMID: 22832604
13. a study of Northwestern Han Chinese found that rs472952 is significantly associated with schizophrenia (SCZ) and rs7537440 is associated with SCZ in females; results provide further evidence that PDE4B may play important roles in the etiology of SCZ PMID: 22160351
14. PDE4B was downregulated and the protein kinase A pathway was activated in castration-resistant LNCaP prostate cancer cells. PDE4B expression was reduced in advanced prostate cancer and PDE4B knockdown promoted castration-resistant growth of LNCaP cells. PMID: 22529021
15. The reported anti-inflammatory activity of bresol might be attributed to its abilities to inhibit PDE4B and thus elevate cAMP levels in human monocytes. PMID: 21854221
16. Overexpression of the PDE4B in diffuse large B-cell lymphoma (DLBCL) impinge on the same genes/pathways that are abnormally active in GC-resistant tumors. PMID: 21742807
17. found a significant association between PDE4B and PD in the haplotype analysis. Sex-specific analyses demonstrated that PDE4B was associated with PD in females. results suggest PDE4B may play a role in the pathophysiology of PD in the Japanese population. PMID: 21184794
18. Molecular dynamic simulations (with data from crystal structure of catalytic domain of PDE4B with cAMP bound) are used to investigate the catalytic mechanism of PDE4B in the hydrolysis of cAMP. PMID: 21595828
19. these data allow the assignment of different PDE4 subtypes to distinct functions of human lung fibroblasts and highlight the predominant role of PDE4B in controlling pathophysiological processes of human lung fibroblasts. PMID: 21520048
20. results do not support a genetic association between tardive dyskinesia and PDE4B PMID: 20436352
21. TCR-dependent signaling activates PDE4B2 and enhances interleukin-2 production in T cells. PMID: 14585965
22. clinically relevant PDE4 and PI3K/AKT inhibitors might be useful in the treatment of Diffuse large B-cell lymphoma and additional B-lymphoid malignancies with increased PDE4B expression PMID: 15331441
23. a mechanistic model whereby DISC1 sequesters phosphodiesterase 4B in resting cells and releases it in an activated state in response to elevated cAMP PMID: 16293762
24. Reverse-transcription polymerase chain reaction confirmed increased expression of GADD45A, BTG2, PDE4B, and CEBPD and downregulation of TOB1 in skeletal muscle intradialysis. PMID: 16997058
25. Compartmentalized PDE4B acts as a sink to drain cAMP from discrete locations, resulting in multiple domains with different cAMP concentrations. PMID: 17088426
26. PDE4B haplotype alters the genetic risk of schizophrenia in the Scottish population complements the known participation of this gene in biological processes associated with mental illness PMID: 17417055
27. A super-short, brain specific isoform of human PDE4B, PDE4B5, was identified. It has cAMP hydrolyzing activity and is inhibited by PDE4 inhibitors. PDE4B5 bind to DISC1. The 16 N-terminal residues are identical to the corresponding residues of PDE4D6. PMID: 17519386
28. Altered DISC1-PDE4B interaction may thus underlie the symptoms of some cases of schizophrenia and depression.(Review) PMID: 17823207
29. Our result suggests that variations at the PDE4B locus may play a significant role in the etiology of SZ in the Japanese population. PMID: 18329668
30. the present observations suggest that dysregulation of intracellular signaling mediated by PDE4B is a significant factor in the cause and expression, respectively, of schizophrenia. PMID: 18394866
31. the PDE4B gene itself does not link to major depressive disorder (MDD) but the elevated mRNA levels of PDE4B might be implicated in the pathophysiology of MDD. PMID: 18785206
32. NDE1, NDEL1 and LIS1, together with their binding partner dynein, associate with DISC1, PDE4B and PDE4D within the cell, and provide evidence that this complex is present at the centrosome. PMID: 18983980
33. There was no strong evidence for association with PDE4B in schizophrenia. PMID: 19632097
34. phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes, and that its up-regulation at the protein level is controlled by complex mechanisms PMID: 19728060
35. Behavioral phenotypes of Disc1 missense mutations in mice and consequences for PDE4B PMID: 17481393

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HGNC: 8781

OMIM: 600127

KEGG: hsa:5142

STRING: 9606.ENSP00000332116

UniGene: Hs.198072