PDE4B

PDE4B, recognized for its role as a phosphodiesterase enzyme, is encoded by the gene situated on human chromosome 2. This enzyme, comprising a 754-amino acid polypeptide, is prominently expressed across various tissues and cell types. PDE4B's primary function is the breakdown of the intracellular second messenger cAMP, thus modulating its levels and impacting cellular processes. It plays a key role in regulating cell behaviors such as proliferation, differentiation, and the inflammatory response. It is implicated in the pathology of diseases including schizophrenia, bipolar disorder, Alzheimer's, and certain cardiovascular conditions. PDE4B represents a significant therapeutic target, making the comprehension of its enzymatic activity and the identification of effective inhibitors crucial for the development of treatments for these diseases.