ENH antibody; ENH1 antibody; Enigma homolog antibody; Enigma like LIM domain protein antibody; Enigma like PDZ and LIM domains protein antibody; Enigma-like PDZ and LIM domains protein antibody; L 9 antibody; L9 antibody; LIM antibody; PDLI5_HUMAN antibody; PDLIM5 antibody; PDZ and LIM domain 5 antibody; PDZ and LIM domain protein 5 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human PDLIM5
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
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May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.
Gene References into Functions
this study shows functional importance of PDLIM5 for proper kAE1 membrane residency, as a crucial linker between kidneyAE1 and actin cytoskeleton-associated proteins in polarized cells PMID: 28045035
PDLIM5 promotes papillary thyroid carcinoma via activation of the Ras-ERK pathway. PMID: 29574154
PDLIM5 was strongly up-regulated during cardiomyogenesis and novel stage-specific isoforms were detected for PDLIM5 PMID: 28139119
Findings provide evidence of shared genetic variants in PDLIM5 gene influencing alcohol dependence, type 2 diabetes, and hypertension. PMID: 27693979
The study provides evidence of several genetic variants within the PDLIM5 gene and interactions between PDLIM5 and steroid use influencing cancer. PMID: 27350677
It can be deduced that the nonsynonymous rs7690296 polymorphism of PDLIM5 could play an important role in the pathophysiology of both bipolar disorder and schizophrenia. PMID: 24064681
PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men. PMID: 22741436
The significant difference in expression of PDLIM5 mRNA in the peripheral blood leukocytes of treatment-naive bipolar (BPD) patients versus that of healthy control subjects suggests that it may be a good biological marker for BPD. PMID: 23031404
LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner. PMID: 21266195
Altered expression of LIM was found in brains and lymphoblastoid cells from patients with bipolar disorder. PMID: 14743183
It is confirmed a decreased expression of LIM in the lymphoblastoid cell lines from patients with bipolar I disorder and schizophrenia. PMID: 15362566
Western blot studies of muscle tissues revealed that ENH4 is present only in skeletal muscle and there is a specific distribution of ENH members between skeletal and cardiac muscles, which is different in human and mouse. PMID: 15555569
Genetic association study revealed the association of single nucleotide polymorphism (SNP)1 (rs10008257) with bipolar disorder. PMID: 16044170
ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors PMID: 16549780
Our investigation indicates that the lower expression levels of LIM mRNA in the peripheral leukocytes are associated with the depressive state and that its recovery after treatment may be an adaptive change induced by the antidepressant. PMID: 16595163
We suggest that the higher expression levels of the PDLIM5 mRNA in the peripheral leukocytes may be a candidate marker for medication-free schizophrenic patients. PMID: 17287082
our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia PMID: 18021463
PDLIM5 gene is associated with recurrent major depressive disorder. PMID: 18197271
tested for an association between three single nucleotide polymorphisms at the PDLIM5 gene and lithium prophylaxis in a Sardinian sample comprised of 155 bipolar patients treated with lithium PMID: 18456508
PDLIM5 may have a minor effect on susceptibility to bipolar disorder in Caucasians. PMID: 18496208
The aim of this study was to investigate the association between PDLIM5 single nucleotide polymorphisms and bipolar disorder in a case-control sample. PMID: 18496210
Our results suggest that PDLIM5 might play a role in susceptibility to bipolar disorder among the Chinese Han population. PMID: 19448850
Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.