PELO Antibody

Datasheet

Code	CSB-PA861124LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA861124LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA861124LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PELO Polyclonal antibody

Uniprot No.

Q9BRX2

Target Names

PELO

Alternative Names

CGI 17 antibody; CGI17 antibody; pelo antibody; PELO_HUMAN antibody; pelota (Drosophila) homolog antibody; pelota homolog antibody; PRO1770 antibody; Protein pelota homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein pelota homolog protein (1-385AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PELO Antibody (Product code: CSB-PA861124LA01HU) is Non-conjugated. For PELO Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA861124LB01HU	PELO Antibody, HRP conjugated	ELISA
FITC	CSB-PA861124LC01HU	PELO Antibody, FITC conjugated
Biotin	CSB-PA861124LD01HU	PELO Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.

Gene References into Functions

Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development. PMID: 27681415
The data suggest that the decay of platelet mRNAs is slowed by the natural loss of the mRNA surveillance and ribosome rescue factor Pelota. PMID: 28213379
Human Pelota compensated for Dom34 functions in quality control of nonstop mRNA in yeast. PMID: 27543824
PELO is a novel regulator of HER-signalling. PMID: 23435426
The non-stop decay mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski complex. PMID: 23667253
Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1. PMID: 21448132
PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs. PMID: 20406461
thrombopoietin-induced in vitro differentiation of primary human cord blood mononuclear cells into megakaryocytes, we observed rapid, progressive CpG methylation of ITGA1, but not PELO or ITGA2. PMID: 17669516

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Eukaryotic release factor 1 family, Pelota subfamily

Tissue Specificity

Ubiquitously expressed.

Database Links

HGNC: 8829

OMIM: 605757

KEGG: hsa:53918

STRING: 9606.ENSP00000274311

UniGene: Hs.644352

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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