PELO

The PELO gene encodes a protein known as Pelonuein, also referred to as PEL or PEL1. This protein plays a crucial role in the regulation of the cell cycle, particularly during mitosis. It functions as a tumor suppressor by inhibiting the progression of cells through the cell cycle, thereby preventing uncontrolled cell growth. PELO is involved in the spindle assembly checkpoint, ensuring proper chromosome alignment before cell division. Dysregulation of PELO is associated with various cancers, including breast, lung, and ovarian cancer. Research into PELO has led to the development of potential therapeutic strategies, including small molecule inhibitors that target PELO to inhibit tumor growth.