PJA2 Antibody

Code CSB-PA003792
Size US$100
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  • Western Blot analysis of Jurkat cells using PJA2 Polyclonal Antibody
  • Western Blot analysis of various cells using PJA2 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
PJA2
Alternative Names
E3 ubiquitin protein ligase Praja2 antibody; E3 ubiquitin-protein ligase Praja-2 antibody; KIAA0438 antibody; Neurodap 1 antibody; Neurodap1 antibody; PJA 2 antibody; PJA2 antibody; PJA2_HUMAN antibody; Praja 2 antibody; Praja 2 RING H2 motif containing antibody; praja ring finger 2 antibody; Praja ring finger 2 E3 ubiquitin protein ligase antibody; Praja2 antibody; RING finger protein 131 antibody; RNF 131 antibody; RNF131 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human PJA2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.
Gene References into Functions
  1. Proper ubiquitin chain assembly by PJA2 requires that Tat first binds its P-TEFb cofactor. PMID: 28345603
  2. The RING ligase praja2 ubiquitylates and degrades Mob, a core component of NDR/LATS kinase and a positive regulator of the tumour-suppressor Hippo cascade. PMID: 23652010
  3. Detection of PJA2-FER fusion mRNA is correlated with poor postoperative survival periods in non-small cell lung cancer. PMID: 23931849
  4. praja2 is a novel cancer-related gene whose expression is linked to the histotype and mutational status of the thyroid tumor. PMID: 22948757
Subcellular Location
Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic density.
Database Links

HGNC: 17481

KEGG: hsa:9867

STRING: 9606.ENSP00000354775

UniGene: Hs.483036

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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