PLEKHA3 Antibody

Code CSB-PA018156GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
PLEKHA3
Alternative Names
PLEKHA3 antibody; FAPP1 antibody; Pleckstrin homology domain-containing family A member 3 antibody; PH domain-containing family A member 3 antibody; Phosphatidylinositol-four-phosphate adapter protein 1 antibody; FAPP-1 antibody; Phosphoinositol 4-phosphate adapter protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human PLEKHA3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane. Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration. Binds preferentially to PtdIns(4)P. Negatively regulates APOB secretion from hepatocytes.
Gene References into Functions
  1. Binding sites on Fapp1 protein for Arf1 and phosphatidylinositol-4-phosphate minimally overlap PMID: 24462251
  2. We report the complete (1)H, (13)C and (15)N resonance assignments of the FAPP1-PH in its free state and those induced by PtdIns(4)P or detergent micelles. PMID: 21298564
  3. Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain. PMID: 21454700
  4. The micelle-bound structure of the FAPP1 pleckstrin homology domain reveals how its prominent wedge independently tubulates Golgi membranes by leaflet penetration. PMID: 20300118
  5. Data show that FAPP1 and 2 are essential components of a phosphatidylinositol 4-phosphate- and ADP-ribosylation factor-regulated machinery that controls generation of constitutive post-Golgi carriers. PMID: 15107860

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Subcellular Location
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Tissue Specificity
Widely expressed.
Database Links

HGNC: 14338

OMIM: 607774

KEGG: hsa:65977

STRING: 9606.ENSP00000234453

UniGene: Hs.41086

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