PLIN3 Antibody

1. High PLIN3 expression is associated with clear cell renal cell carcinoma. PMID: 29773494
2. we found a DPP9-PPP6R3 fusion transcript in one tumor showing a matching genomic 11;19-translocation. Another tumor had a rearrangement of DPP9 with PLIN3. Both rearrangements were associated with diminished expression of the 3' end of DPP9 corresponding to the breakpoints identified by RNA-seq. PMID: 28893231
3. Conserved amphipathic helices mediate lipid droplet targeting of PLIN1, PLIN2, and PLIN3. PMID: 26742848
4. PLIN3 functions are intertwined with the lipogenic pathways implicated in sebaceous lipogenesis, such as desaturation and triglyceride synthesis. PMID: 25039349
5. Postprandial triglyceride rich lipoproteins may be involved in atherosclerotic plaque formation through the regulation of perilipin-2 and perilipin-3 proteins in macrophages. PMID: 25595097
6. Differential expression of PLIN3 and brefeldin A sensitivity may explain differential lipid oxidation efficiency in skeletal muscle among healthy lean, sedentary, and T2 diabetic males. PMID: 26171795
7. Results indicate that microRNAs miR-148a and miR-30a, regulate Tail interacting protein of 47 kDa (TIP47) expression and lipid droplets (LD) in hepatitis C virus infected cells. PMID: 26170028
8. Following exercise training, perilipin 3 protein expression was increased in the adipose tissue of women with polycystic ovary syndrome. PMID: 25342854
9. Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation. PMID: 24632837
10. Rab9-complexed TIP47 plays an essential role for the proper release of hepatitis C viral particles. PMID: 24480419
11. PLIN3 is associated with the synthesis and secretion of PGE2 PMID: 23936516
12. TIP47 plays an essential role in the life cycle of hepatitis C virus. PMID: 23354285
13. studies identified the lipid droplet(LD-associated host protein, Tail-Interacting Protein 47 (TIP47) as a novel NS5A interaction partner; data support a model where TIP47-via its interaction with NS5A-serves as a novel cofactor for HCV infection possibly by integrating LD membranes into the membranous web PMID: 23593007
14. TIP47 is here described for the first time as a viral restriction factor that acts by limiting viral protein synthesis. PMID: 23348195
15. PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content in female skeletal muscle. PMID: 22667335
16. Suppression of TIP47 in HeLa cells facilitated oxidative-stress-induced cell death. PMID: 20556887
17. TIP47 is required for the encounter between Gag and Env, and thus for the generation of infectious HIV-1 particles from primary macrophages. PMID: 20070608
18. can co-localize with lipid storage proteins PMID: 12077142
19. Data show that placental protein 17b (PP17b)is a neutral lipid droplet-associated protein, and its expression is regulated by PKC- and PKA-dependent pathways PMID: 12631276
20. TIP47 binding to HIV-1 envelope glycoprotein (ENV) is required for ENV transport to the trans-golgi network and for its incorportaion into virions and its pathogenicity PMID: 12768012
21. Rab9 GTPase stability on late endosomes required interaction with TIP47 PMID: 15456905
22. TIP47 and adipophilin are components of many, but not all, the lipid droplets in THP-1 cells PMID: 15545278
23. we report the identity of an inhibitor, TIP47, which prevents retinylester hydrolysis catalyzed by GS2 lipase and hormone-sensitive lipase PMID: 16741517
24. Binding of the effector protein TIP47 is important for Rab9 localization. PMID: 16769818
25. The results suggested that the putative hydrophobic cleft is critical for the unique characteristics of TIP47. PMID: 16808905
26. These results show that TIP47 is a cellular cofactor that plays an essential role in Env incorporation, allowing the encounter and the physical association between HIV-1 Gag and Env proteins during the viral assembly process. PMID: 17003132
27. Adipophilin and TIP47 are expressed in LDs of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes. PMID: 18393390
28. The present results suggest that lipid droplets (LD) and LD-associated proteins have protective effects against apoptosis induced by fatty acid-bound albumin by sequestering free fatty acids. PMID: 18832575
29. TIP47 (tail-interacting protein 47 kD) protein levels directly correlate with triglyceride levels; TIP47 may act as a carrier protein for free fatty acids and in this way participates in conversion of macrophages into foam cells PMID: 19286631
30. VV p37 protein associates with host TIP47, Rab9 and CI-MPR. PMID: 19400954
31. TIP47 has apolipoprotein-like properties and reorganizes liposomes into small lipid discs PMID: 19451273

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HGNC: 16893

OMIM: 602702

KEGG: hsa:10226

STRING: 9606.ENSP00000221957

UniGene: Hs.140452