Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
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May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Gene References into Functions
the first report on the transcriptional regulation of hPLSCR4, where Snail was shown to downregulate the expression of Human phospholipid scramblase 4 PMID: 27363667
biochemical and functional characterization of human phospholipid scramblase 4 PMID: 23089641
Crystallographic analysis of mammalian importin alpha1 in complex with the hPLSCR4-NLS reveals this minimal NLS binds specifically and exclusively to the minor binding site of importin alpha PMID: 21690087
SLPI is a ligand for PLSCR1 and PLSCR4, which also interact directly with the CD4 receptor at the cell surface of T lymphocytes PMID: 19333378
Subcellular Location
Membrane; Single-pass type II membrane protein.
Protein Families
Phospholipid scramblase family
Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes.